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Nejnovější publikace z našeho oddělení

Decoding ‘Wntch’: the intertwined Wnt and Notch pathways in development and disease
with Žádné komentáře

Abstract: Multicellularity emerges from the ability of cells to undergo functional differentiation. One of the key mechanisms that enables this coordination is cellular signalling—a series of molecular interactions within or between cells that induce changes in cell behaviour or gene … Read More

Developmental toxicity of fluconazole and 1,2,4-triazole in Xenopus laevis
with Žádné komentáře

Abstract: Fluconazole (FLU) is a widely used antifungal agent frequently detected in surface waters because of its extensive use in medicine, agriculture, and personal care products. Despite concerns about its persistence and developmental toxicity in aquatic species, its effects on … Read More

PRICKLE3 protects VANGL proteins from CK1-mediated phosphorylation and RNF43-mediated degradation
with Žádné komentáře

Abstract: The PRICKLE proteins (PRICKLE1-PRICKLE4) play essential roles in the WNT/planar cell polarity (WNT/PCP) pathway in vertebrates. This signaling system governs cell polarity, tissue architecture, and coordinated cell movements, yet the specific roles and molecular mechanisms of individual PRICKLE members … Read More

The insight into the biology of five homologous lectins produced by the entomopathogenic bacterium and nematode symbiont Photorhabdus laumondii
with Žádné komentáře

Abstract: Photorhabdus laumondii is a well-known bacterium with a complex life cycle involving mutualism with nematodes of the genus Heterorhabditis and pathogenicity towards insect hosts. It provides an excellent model for studying the diverse roles of lectins, saccharide-binding proteins, in … Read More

Inhaled Lead Nanoparticles Enter the Brain through the Olfactory Pathway and Induce Neurodegenerative Changes Resembling Tauopathies
with Žádné komentáře

Abstract: Lead nanoparticles (PbNPs) in air pollution pose a significant threat to human health, especially due to their neurotoxic effects. In this study, we exposed mice to lead(II) oxide nanoparticles (PbONPs) in inhalation chambers to mimic real-life exposure and assess … Read More

In-cell NMR spectroscopy of nucleic acids: Basic concepts, practical aspects, and applications
with Žádné komentáře

Highlights NMR can provide information on the nucleic acids‘ structure, dynamics, and interactions in living cells We overview strategies to acquire and present in-cell NMR data on nucleic acids We provide ‘behind-the-scene’ information vital to comprehending the data meaning Abstract … Read More

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