The new AKTA chromatography system has strengthened our laboratory possibilities and capacities! The first protein purification and extremely immediately successful! AKTA is a compact liquid chromatography system that is used for routine protein purification in research laboratories.Rapidly obtaining … Read More
Abstract: Mineralized tissues, such as bones or teeth, are essential structures of all vertebrates. They enable rapid movement, protection, and food processing, in addition to providing physiological functions. Although the development, regeneration, and pathogenesis of teeth and bones have been … Read More
Abstract: In this study we use comparative genomics to uncover a gene with uncharacterized function (1700011H14Rik/C14orf105/CCDC198), which we hereby name FAME (Factor Associated with Metabolism and Energy). We observe that FAME shows an unusually high evolutionary divergence in birds and … Read More
Laboratories of Dr. Konstantinos Tripsianes (CEITEC MU) and Prof. Vítězslav Bryja (Faculty of Science MU) are looking for new colleagues: (i) Research technician workload: 40 hours per week work tasks: a) general molecular biology tasks: DNA and protein analysis, transformation, … Read More
We cordially invite you to a lecture: Cytonemes in cell signalling – Spreading Wnt signals in development and disease
Srdečně vás zveme na přednášku: Cytonemes in cell signalling – Spreading Wnt signals in development and disease
Abstract: Casein kinases 1 (CK1) are key signaling molecules that have emerged recently as attractive therapeutic targets in particular for the treatment of hematological malignancies. Herein, we report the identification of a new class of potent and highly selective inhibitors … Read More
Abstract: The migratory properties of leukemic cells are commonly associated with their pathological potential and can significantly affect the disease progression. While the research in immunopathology mostly employed powerful indirect methods such as flow cytometry, these cells were rarely observed … Read More
Abstract: Spontaneous bleeds are a leading cause of death in the pediatric JAG1-related liver disease Alagille syndrome (ALGS). We asked whether there are sex differences in bleeding events in patients, whether Jag1Ndr/Ndr mice display bleeds or vascular defects, and whether … Read More
Abstract: Over the past decades an extensive effort has been made to provide a more comprehensive understanding of Wnt signaling, yet many regulatory and structural aspects remain elusive. Among these, the ability of Dishevelled (DVL) protein to relocalize at the … Read More