{"id":9934,"date":"2022-05-23T17:09:19","date_gmt":"2022-05-23T17:09:19","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=9934"},"modified":"2022-12-01T17:09:53","modified_gmt":"2022-12-01T17:09:53","slug":"regulation-of-choroid-plexus-development-and-its-functions-2","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/regulation-of-choroid-plexus-development-and-its-functions-2\/","title":{"rendered":"Regulation of choroid plexus development and its functions"},"content":{"rendered":"\n<p><strong>Abstract:<\/strong><\/p>\n<p>The choroid plexus (ChP) is an extensively vascularized tissue that protrudes into the brain ventricular system of all vertebrates. This highly specialized structure, consisting of the polarized epithelial sheet and underlying stroma, serves a spectrum of functions within the central nervous system (CNS), most notably the production of cerebrospinal fluid (CSF). The epithelial cells of the ChP have the competence to tightly modulate the biomolecule composition of CSF, which acts as a milieu functionally connecting ChP with other brain structures. This review aims to eloquently summarize the current knowledge about the development of ChP. We describe the mechanisms that control its early specification from roof plate followed by the formation of proliferative regions-cortical hem and rhombic lips-feeding later development of ChP. Next, we summarized the current knowledge on the maturation of ChP and mechanisms that control its morphological and cellular diversity. Furthermore, we attempted to review the currently available battery of molecular markers and mouse strains available for the research of ChP, and identified some technological shortcomings that must be overcome to accelerate the ChP research field. Overall, the central principle of this review is to highlight ChP as an intriguing and surprisingly poorly known structure that is vital for the development and function of the whole CNS. We believe that our summary will increase the interest in further studies of ChP that aim to describe the molecular and cellular principles guiding the development and function of this tissue.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"604\" src=\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/plexus-1024x604.png\" alt=\"\" class=\"wp-image-9931\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/plexus-1024x604.png 1024w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/plexus-300x177.png 300w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/plexus-768x453.png 768w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/plexus-848x501.png 848w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/plexus-1120x662.png 1120w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/plexus-560x331.png 560w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/plexus-740x436.png 740w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/plexus-370x218.png 370w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/plexus.png 1208w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>Authors:<\/strong><\/p>\n<p><strong>Petra Kompan\u00edkov\u00e1 1, V\u00edt\u011bzslav Bryja 1 2<\/strong><\/p>\n<p><strong>Affiliations:<\/strong><\/p>\n<p><strong>1 Department of Experimental Biology, Faculty of Science, Masaryk University, 62500, Brno, Czech Republic.<\/strong><\/p>\n<p>2 Department of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, 61265, Brno, Czech Republic.&nbsp;<\/p>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns_08bd03-de{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns_08bd03-de .kt-button{font-weight:normal;font-style:normal;}.kt-btns_08bd03-de .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns_08bd03-de .kt-btn-wrap-0 .kt-button{color:#fff;background:#009900;border-color:#fff;box-shadow:1px 1px 2px 3px rgba(0, 0, 0, 0.2);}.wp-block-kadence-advancedbtn.kt-btns_08bd03-de .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_08bd03-de .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns_08bd03-de .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns_08bd03-de .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_08bd03-de .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kt-btn-align-center kt-btn-tablet-align-inherit kt-btn-mobile-align-inherit kt-btns-wrap kt-btns_08bd03-de\"><div class=\"kt-btn-wrap kt-btn-wrap-0\"><a class=\"kt-button kt-btn-0-action kt-btn-size-standard kt-btn-style-basic kt-btn-svg-show-always kt-btn-has-text-true kt-btn-has-svg-false\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35589983\/\"><span class=\"kt-btn-inner-text\">Read the whole story<\/span><\/a><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Abstract: The choroid plexus (ChP) is an extensively vascularized tissue that protrudes into the brain ventricular system of all vertebrates. This highly specialized structure, consisting of the polarized epithelial sheet and underlying stroma, serves a spectrum of functions within the &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/regulation-of-choroid-plexus-development-and-its-functions-2\/\">Read More<\/a><\/p>\n","protected":false},"author":5,"featured_media":9931,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[256],"tags":[],"class_list":["post-9934","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-new-paper"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Regulation of choroid plexus development and its functions - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/regulation-of-choroid-plexus-development-and-its-functions-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Regulation of choroid plexus development and its functions - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"Abstract: The choroid plexus (ChP) is an extensively vascularized tissue that protrudes into the brain ventricular system of all vertebrates. This highly specialized structure, consisting of the polarized epithelial sheet and underlying stroma, serves a spectrum of functions within the &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/regulation-of-choroid-plexus-development-and-its-functions-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Animal Physiology and Immunology\" \/>\n<meta property=\"article:published_time\" content=\"2022-05-23T17:09:19+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-12-01T17:09:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/plexus.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1208\" \/>\n\t<meta property=\"og:image:height\" content=\"713\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Lucie Nesvadbov\u00e1\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lucie Nesvadbov\u00e1\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/regulation-of-choroid-plexus-development-and-its-functions-2\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/regulation-of-choroid-plexus-development-and-its-functions-2\/\"},\"author\":{\"name\":\"Lucie Nesvadbov\u00e1\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/3119766c8e4c78f08bbbde220469aee6\"},\"headline\":\"Regulation of choroid plexus development and its functions\",\"datePublished\":\"2022-05-23T17:09:19+00:00\",\"dateModified\":\"2022-12-01T17:09:53+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/regulation-of-choroid-plexus-development-and-its-functions-2\/\"},\"wordCount\":290,\"publisher\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/regulation-of-choroid-plexus-development-and-its-functions-2\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/plexus.png\",\"articleSection\":[\"New paper\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/regulation-of-choroid-plexus-development-and-its-functions-2\/\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/regulation-of-choroid-plexus-development-and-its-functions-2\/\",\"name\":\"Regulation of choroid plexus development and its functions - 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