{"id":9927,"date":"2022-03-01T17:00:59","date_gmt":"2022-03-01T17:00:59","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=9927"},"modified":"2022-12-01T17:01:21","modified_gmt":"2022-12-01T17:01:21","slug":"lyn-phosphorylates-and-controls-ror1-surface-dynamics-during-chemotaxis-of-cll-cells-2","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/lyn-phosphorylates-and-controls-ror1-surface-dynamics-during-chemotaxis-of-cll-cells-2\/","title":{"rendered":"Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells"},"content":{"rendered":"\n<p><strong>Abstract:<\/strong><\/p>\n<p>Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are malignancies characterized by the dependence on B-cell receptor (BCR) signaling and by the high expression of ROR1, the cell surface receptor for Wnt-5a. Both, BCR and ROR1 are therapeutic targets in these diseases and the understanding of their mutual cross talk is thus of direct therapeutic relevance. In this study we analyzed the role of Lyn, a kinase from the Src family participating in BCR signaling, as a mediator of the BCR-ROR1 crosstalk. We confirm the functional interaction between Lyn and ROR1 and demonstrate that Lyn kinase efficiently phosphorylates ROR1 in its kinase domain and aids the recruitment of the E3 ligase c-CBL. We show that ROR1 surface dynamics in migrating primary CLL cells as well as chemotactic properties of CLL cells were inhibited by Lyn inhibitor dasatinib. Our data establish Lyn-mediated phosphorylation of ROR1 as a point of crosstalk between BCR and ROR1 signaling pathways.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"912\" height=\"1024\" src=\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/lynrorrr-912x1024.jpg\" alt=\"\" class=\"wp-image-9923\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/lynrorrr-912x1024.jpg 912w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/lynrorrr-267x300.jpg 267w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/lynrorrr-768x862.jpg 768w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/lynrorrr-848x952.jpg 848w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/lynrorrr-560x628.jpg 560w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/lynrorrr-740x830.jpg 740w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/lynrorrr-370x415.jpg 370w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/lynrorrr.jpg 949w\" sizes=\"auto, (max-width: 912px) 100vw, 912px\" \/><\/figure>\n\n\n\n<p><strong>Authors:<\/strong><\/p>\n<p><strong>Zankruti Dave 1<\/strong>, <strong>Olga Vond\u00e1lov\u00e1 Blan\u00e1\u0159ov\u00e1 1<\/strong>, <strong>\u0160t\u011bp\u00e1n \u010cada 1<\/strong>, <strong>Pavl\u00edna Janovsk\u00e1 1<\/strong>, <strong>Nikod\u00e9m Zezula 1<\/strong>, <strong>Martin B\u011bhal 1<\/strong>, Kate\u0159ina Han\u00e1kov\u00e1 2, Sri Ranjani Ganji 2, Pavel Krejci 3 4, <strong>Krist\u00edna G\u00f6m\u00f6ryov\u00e1 1<\/strong>, Helena Peschelov\u00e1 2, Michal \u0160m\u00edda 2 5, Zbyn\u011bk Zdr\u00e1hal 2 6, \u0160\u00e1rka Pavlov\u00e1 2 5, Jana Kota\u0161kov\u00e1 2 5, \u0160\u00e1rka Posp\u00ed\u0161ilov\u00e1 2 5, <strong>V\u00edt\u011bzslav Bryja 1 7<\/strong><\/p>\n<p><strong>Affiliations:<\/strong><\/p>\n<p><strong>1 Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.<\/strong><\/p>\n<p>2 Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.<\/p>\n<p>3Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.<\/p>\n<p>4 International Clinical Research Center, St. Anne&#8217;s University Hospital, Brno, Czech Republic.<\/p>\n<p>5 Department of Internal Medicine-Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.<\/p>\n<p>6 National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic.<\/p>\n<p>7 Department of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic v.v.i., Brno, Czech Republic.<\/p>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns_49e5b7-4d{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns_49e5b7-4d .kt-button{font-weight:normal;font-style:normal;}.kt-btns_49e5b7-4d .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns_49e5b7-4d .kt-btn-wrap-0 .kt-button{color:#fff;background:#009900;border-color:#fff;box-shadow:1px 1px 2px 3px rgba(0, 0, 0, 0.2);}.wp-block-kadence-advancedbtn.kt-btns_49e5b7-4d .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_49e5b7-4d .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns_49e5b7-4d .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns_49e5b7-4d .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_49e5b7-4d .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kt-btn-align-center kt-btn-tablet-align-inherit kt-btn-mobile-align-inherit kt-btns-wrap kt-btns_49e5b7-4d\"><div class=\"kt-btn-wrap kt-btn-wrap-0\"><a class=\"kt-button kt-btn-0-action kt-btn-size-standard kt-btn-style-basic kt-btn-svg-show-always kt-btn-has-text-true kt-btn-has-svg-false\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35295854\/\"><span class=\"kt-btn-inner-text\">Read the whole story<\/span><\/a><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Abstract: Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are malignancies characterized by the dependence on B-cell receptor (BCR) signaling and by the high expression of ROR1, the cell surface receptor for Wnt-5a. Both, BCR and ROR1 are therapeutic &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/lyn-phosphorylates-and-controls-ror1-surface-dynamics-during-chemotaxis-of-cll-cells-2\/\">Read More<\/a><\/p>\n","protected":false},"author":5,"featured_media":9923,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[256],"tags":[],"class_list":["post-9927","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-new-paper"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/lyn-phosphorylates-and-controls-ror1-surface-dynamics-during-chemotaxis-of-cll-cells-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"Abstract: Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are malignancies characterized by the dependence on B-cell receptor (BCR) signaling and by the high expression of ROR1, the cell surface receptor for Wnt-5a. Both, BCR and ROR1 are therapeutic &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/lyn-phosphorylates-and-controls-ror1-surface-dynamics-during-chemotaxis-of-cll-cells-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Animal Physiology and Immunology\" \/>\n<meta property=\"article:published_time\" content=\"2022-03-01T17:00:59+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-12-01T17:01:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/lynrorrr.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"949\" \/>\n\t<meta property=\"og:image:height\" content=\"1065\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Lucie Nesvadbov\u00e1\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lucie Nesvadbov\u00e1\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/lyn-phosphorylates-and-controls-ror1-surface-dynamics-during-chemotaxis-of-cll-cells-2\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/lyn-phosphorylates-and-controls-ror1-surface-dynamics-during-chemotaxis-of-cll-cells-2\/\"},\"author\":{\"name\":\"Lucie Nesvadbov\u00e1\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/3119766c8e4c78f08bbbde220469aee6\"},\"headline\":\"Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells\",\"datePublished\":\"2022-03-01T17:00:59+00:00\",\"dateModified\":\"2022-12-01T17:01:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/lyn-phosphorylates-and-controls-ror1-surface-dynamics-during-chemotaxis-of-cll-cells-2\/\"},\"wordCount\":326,\"publisher\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/lyn-phosphorylates-and-controls-ror1-surface-dynamics-during-chemotaxis-of-cll-cells-2\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2022\/12\/lynrorrr.jpg\",\"articleSection\":[\"New paper\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/lyn-phosphorylates-and-controls-ror1-surface-dynamics-during-chemotaxis-of-cll-cells-2\/\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/lyn-phosphorylates-and-controls-ror1-surface-dynamics-during-chemotaxis-of-cll-cells-2\/\",\"name\":\"Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells - 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