{"id":845,"date":"2018-02-01T09:08:44","date_gmt":"2018-02-01T09:08:44","guid":{"rendered":"http:\/\/www.med.muni.cz\/histology\/ofiz\/?p=845"},"modified":"2019-05-11T19:53:21","modified_gmt":"2019-05-11T19:53:21","slug":"absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/","title":{"rendered":"Absence of differences among low, middle, and high molecular weight hyaluronan in activating murine immune cells in vitro"},"content":{"rendered":"<p>By <a class=\"author size-m workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0141813017306633?via%3Dihub#!\" name=\"baut0005\"><span class=\"content\"><span class=\"text given-name\">Barbora <\/span><span class=\"text surname\">\u0160afr\u00e1nkov\u00e1,&nbsp;<\/span><span id=\"baff0010\" class=\"author-ref\"><\/span><\/span><\/a><a class=\"author size-m workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0141813017306633?via%3Dihub#!\" name=\"baut0010\"><span class=\"content\"><span class=\"text given-name\">Martina <\/span><span class=\"text surname\">Hermannov\u00e1,&nbsp;<\/span><\/span><\/a><a class=\"author size-m workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0141813017306633?via%3Dihub#!\" name=\"baut0015\"><span class=\"content\"><span class=\"text given-name\">Kristina<\/span><span class=\"text surname\"> Ne\u0161porov\u00e1,&nbsp;<\/span><span id=\"baff0015\" class=\"author-ref\"><\/span><\/span><\/a><a class=\"author size-m workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0141813017306633?via%3Dihub#!\" name=\"baut0020\"><span class=\"content\"><span class=\"text given-name\">Vladim\u00edr<\/span><span class=\"text surname\"> Velebn\u00fd, and&nbsp;<\/span><span id=\"baff0005\" class=\"author-ref\"><\/span><\/span><\/a><a class=\"author size-m workspace-trigger\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0141813017306633?via%3Dihub#!\" name=\"baut0025\"><span class=\"content\"><span class=\"text given-name\">Luk\u00e1\u0161<\/span><span class=\"text surname\"> Kubala<\/span><\/span><\/a><\/p>\n<p>Published in: International Journal of Biological Macromolecules<\/p>\n<h3>Abstract<\/h3>\n<div class=\"\">\n<p><span class=\"highlight\">Hyaluronan<\/span> (HA) effects on <span class=\"highlight\">immune<\/span> response are suggested to be dependent on HA <span class=\"highlight\">molecular<\/span> <span class=\"highlight\">weight<\/span> (MW), as <span class=\"highlight\">low<\/span> MW HA should activate <span class=\"highlight\">immune<\/span> <span class=\"highlight\">cells<\/span> in contrast to <span class=\"highlight\">high<\/span> MW HA. However, some current studies do not support this conception and emphasize the importance of the form of preparation of HA, particularly with respect to its purity and origin. We compared the activation of mouse <span class=\"highlight\">immune<\/span> <span class=\"highlight\">cells<\/span> by HA samples (100kDa, 500kDa, and 997kDa) prepared from HA originating from rooster comb, and HA samples (71kDa, 500kDa, and 1000kDa) prepared from pharmacological grade HA originating from Streptococcus equi. Interestingly, in contrast to established theory, only <span class=\"highlight\">middle<\/span> and <span class=\"highlight\">high<\/span> MW HA originating from rooster comb induced the production of tumor necrosis factor-\u03b1 by macrophages and in whole blood. Further, all tested preparations of HA failed to induce the expression of inducible nitric oxide synthase, the production of nitric oxide, or the expression of cyclooxygenase 2 in macrophages and splenocytes. Importantly, all HA samples originating from rooster comb were found to be contaminated by endotoxin (up to 1.23EU\/ml). Hence, <span class=\"highlight\">low<\/span> MW HA did not reveal itself to have significantly higher immunostimulatory activity compared to HA of higher MW.<\/p>\n<p>Link to full article: <a href=\"https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.08.131\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.08.131<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>By Barbora \u0160afr\u00e1nkov\u00e1,&nbsp;Martina Hermannov\u00e1,&nbsp;Kristina Ne\u0161porov\u00e1,&nbsp;Vladim\u00edr Velebn\u00fd, and&nbsp;Luk\u00e1\u0161 Kubala Published in: International Journal of Biological Macromolecules Abstract Hyaluronan (HA) effects on immune response are suggested to be dependent on HA molecular weight (MW), as low MW HA should activate immune cells &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/\">Read More<\/a><\/p>\n","protected":false},"author":3,"featured_media":846,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[256],"tags":[],"class_list":["post-845","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-new-paper"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Absence of differences among low, middle, and high molecular weight hyaluronan in activating murine immune cells in vitro - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Absence of differences among low, middle, and high molecular weight hyaluronan in activating murine immune cells in vitro - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"By Barbora \u0160afr\u00e1nkov\u00e1,&nbsp;Martina Hermannov\u00e1,&nbsp;Kristina Ne\u0161porov\u00e1,&nbsp;Vladim\u00edr Velebn\u00fd, and&nbsp;Luk\u00e1\u0161 Kubala Published in: International Journal of Biological Macromolecules Abstract Hyaluronan (HA) effects on immune response are suggested to be dependent on HA molecular weight (MW), as low MW HA should activate immune cells &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Animal Physiology and Immunology\" \/>\n<meta property=\"article:published_time\" content=\"2018-02-01T09:08:44+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-05-11T19:53:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/safrankova_et_al2018.png\" \/>\n\t<meta property=\"og:image:width\" content=\"673\" \/>\n\t<meta property=\"og:image:height\" content=\"991\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"ofiz_admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"ofiz_admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/\"},\"author\":{\"name\":\"ofiz_admin\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/f0b03016fb58a4293d678fa8d7254794\"},\"headline\":\"Absence of differences among low, middle, and high molecular weight hyaluronan in activating murine immune cells in vitro\",\"datePublished\":\"2018-02-01T09:08:44+00:00\",\"dateModified\":\"2019-05-11T19:53:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/\"},\"wordCount\":248,\"publisher\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/safrankova_et_al2018.png\",\"articleSection\":[\"New paper\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/\",\"name\":\"Absence of differences among low, middle, and high molecular weight hyaluronan in activating murine immune cells in vitro - Department of Animal Physiology and Immunology\",\"isPartOf\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/safrankova_et_al2018.png\",\"datePublished\":\"2018-02-01T09:08:44+00:00\",\"dateModified\":\"2019-05-11T19:53:21+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/#primaryimage\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/safrankova_et_al2018.png\",\"contentUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/safrankova_et_al2018.png\",\"width\":673,\"height\":991},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Absence of differences among low, middle, and high molecular weight hyaluronan in activating murine immune cells in vitro\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#website\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/\",\"name\":\"Department of Animal Physiology and Immunology\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\",\"name\":\"Department of Animal Physiology and Immunology\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/logo_EN.png\",\"contentUrl\":\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/logo_EN.png\",\"width\":1903,\"height\":264,\"caption\":\"Department of Animal Physiology and Immunology\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/f0b03016fb58a4293d678fa8d7254794\",\"name\":\"ofiz_admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/d6956d7fca9c9bca6276ae6f8dd0377c51e51afb41527afefe9fb131b726352d?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/d6956d7fca9c9bca6276ae6f8dd0377c51e51afb41527afefe9fb131b726352d?s=96&d=mm&r=g\",\"caption\":\"ofiz_admin\"},\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/author\/ofiz_admin\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Absence of differences among low, middle, and high molecular weight hyaluronan in activating murine immune cells in vitro - Department of Animal Physiology and Immunology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/","og_locale":"en_US","og_type":"article","og_title":"Absence of differences among low, middle, and high molecular weight hyaluronan in activating murine immune cells in vitro - Department of Animal Physiology and Immunology","og_description":"By Barbora \u0160afr\u00e1nkov\u00e1,&nbsp;Martina Hermannov\u00e1,&nbsp;Kristina Ne\u0161porov\u00e1,&nbsp;Vladim\u00edr Velebn\u00fd, and&nbsp;Luk\u00e1\u0161 Kubala Published in: International Journal of Biological Macromolecules Abstract Hyaluronan (HA) effects on immune response are suggested to be dependent on HA molecular weight (MW), as low MW HA should activate immune cells &hellip; Read More","og_url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/","og_site_name":"Department of Animal Physiology and Immunology","article_published_time":"2018-02-01T09:08:44+00:00","article_modified_time":"2019-05-11T19:53:21+00:00","og_image":[{"width":673,"height":991,"url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/safrankova_et_al2018.png","type":"image\/png"}],"author":"ofiz_admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"ofiz_admin","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/#article","isPartOf":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/"},"author":{"name":"ofiz_admin","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/f0b03016fb58a4293d678fa8d7254794"},"headline":"Absence of differences among low, middle, and high molecular weight hyaluronan in activating murine immune cells in vitro","datePublished":"2018-02-01T09:08:44+00:00","dateModified":"2019-05-11T19:53:21+00:00","mainEntityOfPage":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/"},"wordCount":248,"publisher":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization"},"image":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/#primaryimage"},"thumbnailUrl":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/safrankova_et_al2018.png","articleSection":["New paper"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/","url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/","name":"Absence of differences among low, middle, and high molecular weight hyaluronan in activating murine immune cells in vitro - Department of Animal Physiology and Immunology","isPartOf":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/#primaryimage"},"image":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/#primaryimage"},"thumbnailUrl":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/safrankova_et_al2018.png","datePublished":"2018-02-01T09:08:44+00:00","dateModified":"2019-05-11T19:53:21+00:00","breadcrumb":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/#primaryimage","url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/safrankova_et_al2018.png","contentUrl":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/safrankova_et_al2018.png","width":673,"height":991},{"@type":"BreadcrumbList","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/absence-of-differences-among-low-middle-and-high-molecular-weight-hyaluronan-in-activating-murine-immune-cells-in-vitro\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/ueb1.sci.muni.cz\/ofiz\/"},{"@type":"ListItem","position":2,"name":"Absence of differences among low, middle, and high molecular weight hyaluronan in activating murine immune cells in vitro"}]},{"@type":"WebSite","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#website","url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/","name":"Department of Animal Physiology and Immunology","description":"","publisher":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ueb1.sci.muni.cz\/ofiz\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization","name":"Department of Animal Physiology and Immunology","url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/logo\/image\/","url":"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/logo_EN.png","contentUrl":"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/logo_EN.png","width":1903,"height":264,"caption":"Department of Animal Physiology and Immunology"},"image":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/f0b03016fb58a4293d678fa8d7254794","name":"ofiz_admin","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/d6956d7fca9c9bca6276ae6f8dd0377c51e51afb41527afefe9fb131b726352d?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/d6956d7fca9c9bca6276ae6f8dd0377c51e51afb41527afefe9fb131b726352d?s=96&d=mm&r=g","caption":"ofiz_admin"},"url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/author\/ofiz_admin\/"}]}},"_links":{"self":[{"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/posts\/845","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/comments?post=845"}],"version-history":[{"count":3,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/posts\/845\/revisions"}],"predecessor-version":[{"id":1736,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/posts\/845\/revisions\/1736"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/media\/846"}],"wp:attachment":[{"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/media?parent=845"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/categories?post=845"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/tags?post=845"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}