{"id":8089,"date":"2021-05-04T09:16:45","date_gmt":"2021-05-04T09:16:45","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=8089"},"modified":"2021-05-04T09:21:14","modified_gmt":"2021-05-04T09:21:14","slug":"a-cellular-and-spatial-map-of-the-choroid-plexus-across-brain-ventricles-and-ages-2","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-cellular-and-spatial-map-of-the-choroid-plexus-across-brain-ventricles-and-ages-2\/","title":{"rendered":"A cellular and spatial map of the choroid plexus across brain ventricles and ages"},"content":{"rendered":"\n<p><strong>Abstract:<\/strong><\/p>\n<div id=\"abssec0010\">\n<p>The <a title=\"Learn more about choroid plexus from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/immunology-and-microbiology\/choroid-plexus\">choroid plexus<\/a> (ChP) in each <a title=\"Learn more about brain ventricle from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/immunology-and-microbiology\/brain-ventricle\">brain ventricle<\/a> produces <a title=\"Learn more about cerebrospinal fluid from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/immunology-and-microbiology\/cerebrospinal-fluid\">cerebrospinal fluid<\/a> (CSF) and forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain.<\/p>\n<\/div>\n\n\n<style>#kt-layout-id_227a89-0e > .kt-row-column-wrap{align-content:start;}:where(#kt-layout-id_227a89-0e > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}#kt-layout-id_227a89-0e > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var( --global-kb-row-default-top, 25px );padding-bottom:var( --global-kb-row-default-bottom, 25px );padding-top:0px;padding-bottom:0px;grid-template-columns:minmax(0, calc(45% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)))minmax(0, calc(55% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)));}#kt-layout-id_227a89-0e > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){#kt-layout-id_227a89-0e > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr) minmax(0, 2fr);}}@media all and (max-width: 767px){#kt-layout-id_227a89-0e > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style>\n<div class=\"wp-block-kadence-rowlayout alignnone\"><div id=\"kt-layout-id_227a89-0e\" class=\"kt-row-layout-inner  kt-layout-id_227a89-0e\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-gutter-default kt-v-gutter-default kt-row-valign-top kt-row-layout-right-golden kt-tab-layout-inherit kt-m-colapse-left-to-right kt-mobile-layout-row kt-custom-first-width-45 kt-custom-second-width-55\"><style>.kadence-column_d43e16-64 > .kt-inside-inner-col{border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;}.kadence-column_d43e16-64 > .kt-inside-inner-col,.kadence-column_d43e16-64 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column_d43e16-64 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column_d43e16-64 > .kt-inside-inner-col{flex-direction:column;}.kadence-column_d43e16-64 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column_d43e16-64 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column_d43e16-64{position:relative;}@media all and (max-width: 1024px){.kadence-column_d43e16-64 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column_d43e16-64 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column inner-column-1 kadence-column_d43e16-64\"><div class=\"kt-inside-inner-col\">\n<div id=\"abssec0010\">\n<p>We delineate diverse cell types, subtypes, cell states, and expression programs in epithelial and mesenchymal cells across ages and ventricles. In the developing ChP, we predict a common progenitor pool for epithelial and neuronal cells, validated by lineage tracing. Epithelial and fibroblast cells show regionalized expression by ventricle, starting at embryonic stages and persisting with age, with a dramatic transcriptional shift with maturation, and a smaller shift in each aged cell type. With aging, epithelial cells upregulate host-defense programs, and resident macrophages upregulate interleukin-1\u03b2 (IL-1\u03b2) signaling genes. Our atlas reveals cellular diversity, architecture and signaling across ventricles during development, maturation, and aging of the ChP-brain barrier.<\/p>\n<\/div>\n<\/div><\/div>\n\n\n<style>.kadence-column_e868d9-a1 > .kt-inside-inner-col{border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;}.kadence-column_e868d9-a1 > .kt-inside-inner-col,.kadence-column_e868d9-a1 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column_e868d9-a1 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column_e868d9-a1 > .kt-inside-inner-col{flex-direction:column;}.kadence-column_e868d9-a1 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column_e868d9-a1 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column_e868d9-a1{position:relative;}@media all and (max-width: 1024px){.kadence-column_e868d9-a1 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column_e868d9-a1 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column inner-column-2 kadence-column_e868d9-a1\"><div class=\"kt-inside-inner-col\">\n<div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/05\/cellpaper.png\" alt=\"\" class=\"wp-image-8073\" width=\"422\" height=\"447\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/05\/cellpaper.png 540w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/05\/cellpaper-283x300.png 283w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/05\/cellpaper-370x393.png 370w\" sizes=\"auto, (max-width: 422px) 100vw, 422px\" \/><\/figure><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns_8b7041-c5{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns_8b7041-c5 .kt-button{font-weight:normal;font-style:normal;}.kt-btns_8b7041-c5 .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns_8b7041-c5 .kt-btn-wrap-0 .kt-button{color:#fff;background:#009900;border-color:#fff;box-shadow:1px 1px 2px 3px rgba(0, 0, 0, 0.2);}.wp-block-kadence-advancedbtn.kt-btns_8b7041-c5 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_8b7041-c5 .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns_8b7041-c5 .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns_8b7041-c5 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_8b7041-c5 .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kt-btn-align-center kt-btn-tablet-align-inherit kt-btn-mobile-align-inherit kt-btns-wrap kt-btns_8b7041-c5\"><div class=\"kt-btn-wrap kt-btn-wrap-0\"><a class=\"kt-button kt-btn-0-action kt-btn-size-standard kt-btn-style-basic kt-btn-svg-show-always kt-btn-has-text-true kt-btn-has-svg-false\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33932339\/\"><span class=\"kt-btn-inner-text\">Read the whole story<\/span><\/a><\/div><\/div>\n\n\n\n<p><strong>Authors:<\/strong><\/p>\n<p>Neil Dani <sup>1<\/sup>, Rebecca Herbst <sup>2<\/sup>, Cristin McCabe <sup>3<\/sup>, Gilad Green <sup>4<\/sup>, <strong>Karol Kaiser <sup>5<\/sup><\/strong>, Joshua Head <sup>1<\/sup>, Jin Cui <sup>1<\/sup>, Frederick Shipley <sup>6<\/sup>, Ahram Jang <sup>1<\/sup>, Danielle Dionne <sup>3<\/sup>, Lan Nguyen <sup>3<\/sup>, Christopher Rodman <sup>3<\/sup>, Samantha Riesenfeld <sup>3<\/sup>, Jan Prochazka <sup>7<\/sup>, Michaela Prochazkova <sup>7<\/sup>, Radislav Sedlacek <sup>7<\/sup>, Feng Zhang <sup>8<\/sup>, <strong>Vitezslav Bryja <sup>5<\/sup><\/strong>, Orit Rozenblatt-Rosen <sup>3<\/sup>, Naomi Habib <sup>9<\/sup>, Aviv Regev <sup>10<\/sup>, Maria K Lehtinen <sup>11<\/sup><\/p>\n\n\n\n<div style=\"height:70px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>&nbsp;&nbsp;&nbsp; 1&nbsp;&nbsp;&nbsp; Department of Pathology, Boston Children&#8217;s Hospital, Boston, MA 02115, USA.<\/p>\n<p>&nbsp;&nbsp;&nbsp; 2&nbsp;&nbsp;&nbsp; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.<\/p>\n<p>&nbsp;&nbsp;&nbsp; 3&nbsp;&nbsp;&nbsp; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<\/p>\n<p>&nbsp;&nbsp;&nbsp; 4&nbsp;&nbsp;&nbsp; Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem 9190401, Israel.<\/p>\n<p>&nbsp;&nbsp;<strong>&nbsp; 5&nbsp;&nbsp;&nbsp; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno 611 37, Czech Republic.<\/strong><\/p>\n<p>&nbsp;&nbsp;&nbsp; 6&nbsp;&nbsp;&nbsp; Department of Pathology, Boston Children&#8217;s Hospital, Boston, MA 02115, USA; Graduate Program in Biophysics, Harvard University, Cambridge, MA 02115, USA.<\/p>\n<p>&nbsp;&nbsp;&nbsp; 7&nbsp;&nbsp;&nbsp; Czech Centre for Phenogenomics and Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the CAS, Prague 142 20, Czech Republic.<\/p>\n<p>&nbsp;&nbsp;&nbsp; 8&nbsp;&nbsp;&nbsp; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<\/p>\n<p>&nbsp;&nbsp;&nbsp; 9&nbsp;&nbsp;&nbsp; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem 9190401, Israel. Electronic address: naomi.habib@mail.huji.ac.il.<\/p>\n<p>&nbsp;&nbsp;&nbsp; 10&nbsp;&nbsp;&nbsp; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address: aviv.regev.sc@gmail.com.<\/p>\n<p>&nbsp;&nbsp;&nbsp; 11&nbsp;&nbsp;&nbsp; Department of Pathology, Boston Children&#8217;s Hospital, Boston, MA 02115, USA; Graduate Program in Biophysics, Harvard University, Cambridge, MA 02115, USA. Electronic address: maria.lehtinen@childrens.harvard.edu.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract: The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain. We delineate diverse &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-cellular-and-spatial-map-of-the-choroid-plexus-across-brain-ventricles-and-ages-2\/\">Read More<\/a><\/p>\n","protected":false},"author":5,"featured_media":8073,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[256],"tags":[],"class_list":["post-8089","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-new-paper"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A cellular and spatial map of the choroid plexus across brain ventricles and ages - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-cellular-and-spatial-map-of-the-choroid-plexus-across-brain-ventricles-and-ages-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A cellular and spatial map of the choroid plexus across brain ventricles and ages - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"Abstract: The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain. We delineate diverse &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-cellular-and-spatial-map-of-the-choroid-plexus-across-brain-ventricles-and-ages-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Animal Physiology and Immunology\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-04T09:16:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-05-04T09:21:14+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/05\/cellpaper.png\" \/>\n\t<meta property=\"og:image:width\" content=\"540\" \/>\n\t<meta property=\"og:image:height\" content=\"573\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Lucie Nesvadbov\u00e1\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lucie Nesvadbov\u00e1\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-cellular-and-spatial-map-of-the-choroid-plexus-across-brain-ventricles-and-ages-2\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-cellular-and-spatial-map-of-the-choroid-plexus-across-brain-ventricles-and-ages-2\/\"},\"author\":{\"name\":\"Lucie Nesvadbov\u00e1\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/3119766c8e4c78f08bbbde220469aee6\"},\"headline\":\"A cellular and spatial map of the choroid plexus across brain ventricles and ages\",\"datePublished\":\"2021-05-04T09:16:45+00:00\",\"dateModified\":\"2021-05-04T09:21:14+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-cellular-and-spatial-map-of-the-choroid-plexus-across-brain-ventricles-and-ages-2\/\"},\"wordCount\":536,\"publisher\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-cellular-and-spatial-map-of-the-choroid-plexus-across-brain-ventricles-and-ages-2\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/05\/cellpaper.png\",\"articleSection\":[\"New paper\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-cellular-and-spatial-map-of-the-choroid-plexus-across-brain-ventricles-and-ages-2\/\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-cellular-and-spatial-map-of-the-choroid-plexus-across-brain-ventricles-and-ages-2\/\",\"name\":\"A cellular and spatial map of the choroid plexus across brain ventricles and ages - 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Here, we construct a single-cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain. 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