{"id":8004,"date":"2021-04-29T12:33:09","date_gmt":"2021-04-29T12:33:09","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=8004"},"modified":"2021-04-29T14:41:03","modified_gmt":"2021-04-29T14:41:03","slug":"development-presents-karol-kaiser-and-choroid-plexus-12-5-2021","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/","title":{"rendered":"Our work recently accepted in Development & highlighted in Development presents"},"content":{"rendered":"\n
Our article has been chosen by the Development editor Paola Arlotta (Harvard Stem Cell Institute) and selected for the monthly webinar “Development presents ….”<\/a> !<\/h5>\n
The topic will be introduced by the first author Karol Kaiser, Ph.D.:<\/h5>\n

\u201eMEIS-WNT5A axis regulates development of 4th ventricle choroid plexus<\/strong>\u201c<\/h4>\n
on Wednesday 12th of May, at 17.00.<\/strong><\/span><\/h5>\n
If you are interested, register here:<\/strong> https:\/\/thenode.biologists.com\/development-presents-may-webinar\/development-presents\/<\/a><\/h5>\n\n\n\n
\"\"<\/figure>\n\n\n\n
<\/div>\n\n\n\n

Title of the paper: MEIS-WNT5A axis regulates development of 4th ventricle choroid plexus<\/strong><\/p>\n

Karol Kaiser, Ahram Jang, Petra Kompan\u00edkov\u00e1, Melody P. Lun, Jan Proch\u00e1zka, Ondrej Machon, Neil Dani, Michaela Proch\u00e1zkov\u00e1, Benoit Laurent, Daniel Gyllborg, Ren\u00e9e van Amerongen, , Ryann M. Fame, Suhasini Gupta, Feizhen Wu, Roger A. Barker, Ivana Bukov\u00e1, Radislav Sedl\u00e1\u010dek, Zbyn\u011bk Kozm\u00edk, Ernest Arenas, Maria K. Lehtinen* and V\u00edt\u011bzslav Bryja*<\/p>\n

Abstract:<\/strong><\/p>\n

The choroid plexus (ChP) produces cerebrospinal fluid and forms a critical brain barrier. ChP tissues form in each brain ventricle, each one adopting a distinct shape, but remarkably little is known about the mechanisms underlying ChP development.  Here, we show that epithelial WNT5A is critical for determining fourth ventricle (4V)  ChP morphogenesis and size. Systemic Wnt5a knockout, or forced Wnt5a overexpression beginning at E10.5, profoundly reduced ChP size and development.<\/p>\n

 However, Wnt5a expression was enriched in Foxj1-positive epithelial cells of 4V ChP plexus, and its conditional deletion in these cells affected the branched, villous morphology of the 4V ChP. We found that WNT5A was enriched in epithelial cells localized to the distal tips of 4V ChP villi, where WNT5A acted locally to activate noncanonical Wnt signaling via Ror1\/Ror2 receptors. During 4V ChP development, MEIS1 bound to the proximal Wnt5a promoter, and gain- and loss-of-function approaches demonstrated that MEIS1 regulated Wnt5a expression. Collectively, our findings demonstrate a dual function of WNT5A in ChP development and identify MEIS transcription factors as upstream regulators of Wnt5a in the 4V ChP epithelium.<\/p>\n

Link to the preprint of the paper: https:\/\/www.biorxiv.org\/content\/10.1101\/2020.05.07.082370v1<\/a><\/p>\n

Accepted in Development<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Our article has been chosen by the Development editor Paola Arlotta (Harvard Stem Cell Institute) and selected for the monthly webinar “Development presents ….” ! The topic will be introduced by the first author Karol Kaiser, Ph.D.: \u201eMEIS-WNT5A axis regulates … Read More<\/a><\/p>\n","protected":false},"author":5,"featured_media":8014,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[412],"tags":[304],"class_list":["post-8004","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bryjalab","tag-bryjalab"],"yoast_head":"\nOur work recently accepted in Development & highlighted in Development presents - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Our work recently accepted in Development & highlighted in Development presents - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"Our article has been chosen by the Development editor Paola Arlotta (Harvard Stem Cell Institute) and selected for the monthly webinar “Development presents ….” ! The topic will be introduced by the first author Karol Kaiser, Ph.D.: \u201eMEIS-WNT5A axis regulates … Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Animal Physiology and Immunology\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-29T12:33:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-04-29T14:41:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/04\/chorownt5acover.png\" \/>\n\t<meta property=\"og:image:width\" content=\"908\" \/>\n\t<meta property=\"og:image:height\" content=\"831\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Lucie Nesvadbov\u00e1\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lucie Nesvadbov\u00e1\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/\"},\"author\":{\"name\":\"Lucie Nesvadbov\u00e1\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/3119766c8e4c78f08bbbde220469aee6\"},\"headline\":\"Our work recently accepted in Development & highlighted in Development presents\",\"datePublished\":\"2021-04-29T12:33:09+00:00\",\"dateModified\":\"2021-04-29T14:41:03+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/\"},\"wordCount\":355,\"publisher\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/04\/chorownt5acover.png\",\"keywords\":[\"Bryjalab\"],\"articleSection\":[\"Bryjalab\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/\",\"name\":\"Our work recently accepted in Development & highlighted in Development presents - Department of Animal Physiology and Immunology\",\"isPartOf\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/04\/chorownt5acover.png\",\"datePublished\":\"2021-04-29T12:33:09+00:00\",\"dateModified\":\"2021-04-29T14:41:03+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/#primaryimage\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/04\/chorownt5acover.png\",\"contentUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/04\/chorownt5acover.png\",\"width\":908,\"height\":831},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Our work recently accepted in Development & highlighted in Development presents\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#website\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/\",\"name\":\"Department of Animal Physiology and Immunology\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\",\"name\":\"Department of Animal Physiology and Immunology\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/logo_EN.png\",\"contentUrl\":\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/logo_EN.png\",\"width\":1903,\"height\":264,\"caption\":\"Department of Animal Physiology and Immunology\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/3119766c8e4c78f08bbbde220469aee6\",\"name\":\"Lucie Nesvadbov\u00e1\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/a91adf81f15a662a55b84fac48c8a8a4f22879e0ab9141bb8487b53bb898b6a6?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/a91adf81f15a662a55b84fac48c8a8a4f22879e0ab9141bb8487b53bb898b6a6?s=96&d=mm&r=g\",\"caption\":\"Lucie Nesvadbov\u00e1\"},\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/author\/nesvadbova\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Our work recently accepted in Development & highlighted in Development presents - Department of Animal Physiology and Immunology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/","og_locale":"en_US","og_type":"article","og_title":"Our work recently accepted in Development & highlighted in Development presents - Department of Animal Physiology and Immunology","og_description":"Our article has been chosen by the Development editor Paola Arlotta (Harvard Stem Cell Institute) and selected for the monthly webinar “Development presents ….” ! The topic will be introduced by the first author Karol Kaiser, Ph.D.: \u201eMEIS-WNT5A axis regulates … Read More","og_url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/","og_site_name":"Department of Animal Physiology and Immunology","article_published_time":"2021-04-29T12:33:09+00:00","article_modified_time":"2021-04-29T14:41:03+00:00","og_image":[{"width":908,"height":831,"url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/04\/chorownt5acover.png","type":"image\/png"}],"author":"Lucie Nesvadbov\u00e1","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Lucie Nesvadbov\u00e1","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/#article","isPartOf":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/"},"author":{"name":"Lucie Nesvadbov\u00e1","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/3119766c8e4c78f08bbbde220469aee6"},"headline":"Our work recently accepted in Development & highlighted in Development presents","datePublished":"2021-04-29T12:33:09+00:00","dateModified":"2021-04-29T14:41:03+00:00","mainEntityOfPage":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/"},"wordCount":355,"publisher":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization"},"image":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/#primaryimage"},"thumbnailUrl":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/04\/chorownt5acover.png","keywords":["Bryjalab"],"articleSection":["Bryjalab"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/","url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/","name":"Our work recently accepted in Development & highlighted in Development presents - Department of Animal Physiology and Immunology","isPartOf":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/#primaryimage"},"image":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/#primaryimage"},"thumbnailUrl":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/04\/chorownt5acover.png","datePublished":"2021-04-29T12:33:09+00:00","dateModified":"2021-04-29T14:41:03+00:00","breadcrumb":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/#primaryimage","url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/04\/chorownt5acover.png","contentUrl":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/04\/chorownt5acover.png","width":908,"height":831},{"@type":"BreadcrumbList","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/development-presents-karol-kaiser-and-choroid-plexus-12-5-2021\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/ueb1.sci.muni.cz\/ofiz\/"},{"@type":"ListItem","position":2,"name":"Our work recently accepted in Development & highlighted in Development presents"}]},{"@type":"WebSite","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#website","url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/","name":"Department of Animal Physiology and Immunology","description":"","publisher":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ueb1.sci.muni.cz\/ofiz\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization","name":"Department of Animal Physiology and Immunology","url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/logo\/image\/","url":"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/logo_EN.png","contentUrl":"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/logo_EN.png","width":1903,"height":264,"caption":"Department of Animal Physiology and Immunology"},"image":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/3119766c8e4c78f08bbbde220469aee6","name":"Lucie Nesvadbov\u00e1","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/a91adf81f15a662a55b84fac48c8a8a4f22879e0ab9141bb8487b53bb898b6a6?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a91adf81f15a662a55b84fac48c8a8a4f22879e0ab9141bb8487b53bb898b6a6?s=96&d=mm&r=g","caption":"Lucie Nesvadbov\u00e1"},"url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/author\/nesvadbova\/"}]}},"_links":{"self":[{"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/posts\/8004","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/comments?post=8004"}],"version-history":[{"count":9,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/posts\/8004\/revisions"}],"predecessor-version":[{"id":8024,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/posts\/8004\/revisions\/8024"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/media\/8014"}],"wp:attachment":[{"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/media?parent=8004"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/categories?post=8004"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/tags?post=8004"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}