{"id":7462,"date":"2021-01-15T09:28:36","date_gmt":"2021-01-15T09:28:36","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=7462"},"modified":"2021-01-15T09:28:38","modified_gmt":"2021-01-15T09:28:38","slug":"modulation-of-differentiation-of-embryonic-stem-cells-by-polypyrrole-the-impact-on-neurogenesis","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/modulation-of-differentiation-of-embryonic-stem-cells-by-polypyrrole-the-impact-on-neurogenesis\/","title":{"rendered":"Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis"},"content":{"rendered":"\n<h5><strong>Abstract:<\/strong><\/h5>\n<p>The active role of biomaterials in the regeneration of tissues and their ability to modulate the behavior of stem cells in terms of their differentiation is highly advantageous. Here, polypyrrole, as a representantive of electro-conducting materials, is found to modulate the behavior of embryonic stem cells. Concretely, the aqueous extracts of polypyrrole induce neurogenesis within embryonic bodies formed from embryonic stem cells.<\/p>\n<p>This finding led to an effort to determine the physiological cascade which is responsible for this effect. The polypyrrole modulates signaling pathways of Akt and ERK kinase through their phosphorylation. These effects are related to the presence of low-molecular-weight compounds present in aqueous polypyrrole extracts, determined by mass spectroscopy.<\/p>\n<p>The results show that consequences related to the modulation of stem cell differentiation must also be taken into account when polypyrrole is considered as a biomaterial.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"541\" src=\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/01\/kasia_clanek1-1024x541.jpg\" alt=\"\" class=\"wp-image-7463\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/01\/kasia_clanek1-1024x541.jpg 1024w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/01\/kasia_clanek1-300x158.jpg 300w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/01\/kasia_clanek1-768x405.jpg 768w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/01\/kasia_clanek1-560x296.jpg 560w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/01\/kasia_clanek1-848x448.jpg 848w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/01\/kasia_clanek1-740x390.jpg 740w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/01\/kasia_clanek1-370x195.jpg 370w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2021\/01\/kasia_clanek1.jpg 1633w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<h5><strong>Authors:<\/strong><\/h5>\n<p>Kate\u0159ina Skopalov\u00e1<sup>1<\/sup>, <strong>Katarzyna Anna Radaszkiewicz<sup>2<\/sup><\/strong>, V\u011bra Ka\u0161p\u00e1rkov\u00e1<sup>1,3<\/sup>, Jaroslav Stejskal<sup>4<\/sup>, Patrycja Bober<sup>4<\/sup>, Ita Junkar<sup>5<\/sup>, Miran Mozeti\u010d<sup>5<\/sup>, Zdenka Cap\u00e1kov\u00e1<sup>1<\/sup>, Mari\u00e1n Lehock\u00fd<sup>1,3<\/sup>, Martina Ka\u0161parov\u00e1<sup>1<\/sup>, <strong>Ji\u0159\u00ed Pachern\u00edk<sup>2<\/sup><\/strong>, and Petr Humpol\u00ed\u010dek<sup>1,3<\/sup><\/p>\n<p>\u00a0<\/p>\n<p>1 Centre of Polymer Systems, Tomas Bata University in Zl\u00edn, 760 01 Zl\u00edn, Czech Republic<\/p>\n<p><strong>2 Department of Experimental Biology, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic<\/strong><\/p>\n<p>3 Faculty of Technology, Tomas Bata University in Zl\u00edn, 760 01 Zl\u00edn, Czech Republic<\/p>\n<p>4 Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06 Prague, Czech Republic<\/p>\n<p>5 Department of Surface Engineering, Jo\u017eef Stefan Institute, Jamova cesta 39, SI-1000 Ljubljana, Slovenia<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns_b49f6d-c2{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns_b49f6d-c2 .kt-button{font-weight:normal;font-style:normal;}.kt-btns_b49f6d-c2 .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns_b49f6d-c2 .kt-btn-wrap-0 .kt-button{color:#fff;background:#009900;border-color:#fff;box-shadow:1px 1px 2px 3px rgba(0, 0, 0, 0.2);}.wp-block-kadence-advancedbtn.kt-btns_b49f6d-c2 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_b49f6d-c2 .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns_b49f6d-c2 .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns_b49f6d-c2 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_b49f6d-c2 .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kt-btn-align-center kt-btn-tablet-align-inherit kt-btn-mobile-align-inherit kt-btns-wrap kt-btns_b49f6d-c2\"><div class=\"kt-btn-wrap kt-btn-wrap-0\"><a class=\"kt-button kt-btn-0-action kt-btn-size-standard kt-btn-style-basic kt-btn-svg-show-always kt-btn-has-text-true kt-btn-has-svg-false\" href=\"https:\/\/www.mdpi.com\/1422-0067\/22\/2\/501\"><span class=\"kt-btn-inner-text\">Read the whole story<\/span><\/a><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Abstract: The active role of biomaterials in the regeneration of tissues and their ability to modulate the behavior of stem cells in terms of their differentiation is highly advantageous. Here, polypyrrole, as a representantive of electro-conducting materials, is found to &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/modulation-of-differentiation-of-embryonic-stem-cells-by-polypyrrole-the-impact-on-neurogenesis\/\">Read More<\/a><\/p>\n","protected":false},"author":5,"featured_media":7463,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[252],"tags":[],"class_list":["post-7462","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nova-publikace"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/modulation-of-differentiation-of-embryonic-stem-cells-by-polypyrrole-the-impact-on-neurogenesis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"Abstract: The active role of biomaterials in the regeneration of tissues and their ability to modulate the behavior of stem cells in terms of their differentiation is highly advantageous. 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