{"id":7244,"date":"2020-12-18T14:48:50","date_gmt":"2020-12-18T14:48:50","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=7244"},"modified":"2020-12-18T14:48:51","modified_gmt":"2020-12-18T14:48:51","slug":"vitezslav-bryja-and-pavlina-janovska-awarded-as-muni-scientists","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/vitezslav-bryja-and-pavlina-janovska-awarded-as-muni-scientists\/","title":{"rendered":"Vitezslav Bryja and Pavlina Janovska awarded as MUNI Scientists"},"content":{"rendered":"\n<h5>Selected scientists from Masaryk University were <strong>awarded for their outstanding research results and significant achievements in the field of research<\/strong> from 2019 to 2020 by the Vice-Rector for Research and Doctoral Studies prof. \u0160\u00e1rka Posp\u00ed\u0161ilov\u00e1.<\/h5>\n\n\n<style>#kt-layout-id_158467-0a > .kt-row-column-wrap{align-content:start;}:where(#kt-layout-id_158467-0a > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}#kt-layout-id_158467-0a > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var( --global-kb-row-default-top, 25px );padding-bottom:var( --global-kb-row-default-bottom, 25px );padding-top:0px;padding-bottom:0px;grid-template-columns:minmax(0, calc(30% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)))minmax(0, calc(70% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)));}#kt-layout-id_158467-0a > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){#kt-layout-id_158467-0a > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr) minmax(0, 2fr);}}@media all and (max-width: 767px){#kt-layout-id_158467-0a > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style>\n<div class=\"wp-block-kadence-rowlayout alignnone\"><div id=\"kt-layout-id_158467-0a\" class=\"kt-row-layout-inner  kt-layout-id_158467-0a\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-gutter-default kt-v-gutter-default kt-row-valign-top kt-row-layout-right-golden kt-tab-layout-inherit kt-m-colapse-left-to-right kt-mobile-layout-row kt-custom-first-width-30 kt-custom-second-width-70\"><style>.kadence-column_a1cc9e-fc > .kt-inside-inner-col{border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;}.kadence-column_a1cc9e-fc > .kt-inside-inner-col,.kadence-column_a1cc9e-fc > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column_a1cc9e-fc > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column_a1cc9e-fc > .kt-inside-inner-col{flex-direction:column;}.kadence-column_a1cc9e-fc > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column_a1cc9e-fc > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column_a1cc9e-fc{position:relative;}@media all and (max-width: 1024px){.kadence-column_a1cc9e-fc > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column_a1cc9e-fc > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column inner-column-1 kadence-column_a1cc9e-fc\"><div class=\"kt-inside-inner-col\">\n<h5>Among the awarded successful scientists are <a href=\"https:\/\/www.sci.muni.cz\/ofiz\/en\/bryja\/people\/\"><strong>prof. V\u00edt\u011bzslav Bryja<\/strong><\/a> and <a href=\"https:\/\/www.sci.muni.cz\/ofiz\/en\/bryja\/people\/\"><strong>Dr. Pavl\u00edna Janovsk\u00e1<\/strong><\/a>, who focus on Wnt signaling and its role in cell biology and in several malignancies, including chronic lymphocytic leukemia (CLL).<\/h5>\n<h5>During the first stage of the discovery process, their data showed that the non-canonical Wnt signaling branch is one of the driving forces of CLL pathogenesis.<\/h5>\n<\/div><\/div>\n\n\n<style>.kadence-column_08bf4a-be > .kt-inside-inner-col{border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;}.kadence-column_08bf4a-be > .kt-inside-inner-col,.kadence-column_08bf4a-be > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column_08bf4a-be > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column_08bf4a-be > .kt-inside-inner-col{flex-direction:column;}.kadence-column_08bf4a-be > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column_08bf4a-be > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column_08bf4a-be{position:relative;}@media all and (max-width: 1024px){.kadence-column_08bf4a-be > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column_08bf4a-be > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column inner-column-2 kadence-column_08bf4a-be\"><div class=\"kt-inside-inner-col\">\n<div style=\"height:22px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/12\/Janovska_et_Bryja-1024x707.png\" alt=\"\" class=\"wp-image-7225\" width=\"514\" height=\"355\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/12\/Janovska_et_Bryja-1024x707.png 1024w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/12\/Janovska_et_Bryja-300x207.png 300w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/12\/Janovska_et_Bryja-768x530.png 768w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/12\/Janovska_et_Bryja.png 1087w\" sizes=\"auto, (max-width: 514px) 100vw, 514px\" \/><\/figure><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n\n\n\n<h5>Later, they have managed to use specific inhibitors of this pathway to block the disease development in a well-described CLL mouse model. Finally, in collaboration with the colleagues from the MUNI Chemistry department, they have managed to develop novel small-molecule inhibitors of the pathway, which were shown to be effective in preclinical models of the disease and currently aim at clinical phases of testing to become a novel form of therapy for leukemia, lymphoma and other malignancies.<\/h5>\n\n\n\n<h5>You can read more about their research on the website of the <a href=\"https:\/\/www.sci.muni.cz\/ofiz\/en\/bryja\/\"><strong>Bryjalab<\/strong> <\/a>research group.<\/h5>\n<h5><strong>Congratulations!<\/strong> \ud83c\udf7e\ud83c\udf89<\/h5>\n<h5>You can see the medallions of other awarded scientists <a href=\"https:\/\/gamu.muni.cz\/en\/aktuality\/muni-scientist-awards-2020\">here<\/a>.<\/h5>\n","protected":false},"excerpt":{"rendered":"<p>Selected scientists from Masaryk University were awarded for their outstanding research results and significant achievements in the field of research from 2019 to 2020 by the Vice-Rector for Research and Doctoral Studies prof. \u0160\u00e1rka Posp\u00ed\u0161ilov\u00e1. Among the awarded successful scientists &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/vitezslav-bryja-and-pavlina-janovska-awarded-as-muni-scientists\/\">Read More<\/a><\/p>\n","protected":false},"author":5,"featured_media":7236,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[412,267],"tags":[304],"class_list":["post-7244","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bryjalab","category-news","tag-bryjalab"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Vitezslav Bryja and Pavlina Janovska awarded as MUNI Scientists - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/vitezslav-bryja-and-pavlina-janovska-awarded-as-muni-scientists\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vitezslav Bryja and Pavlina Janovska awarded as MUNI Scientists - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"Selected scientists from Masaryk University were awarded for their outstanding research results and significant achievements in the field of research from 2019 to 2020 by the Vice-Rector for Research and Doctoral Studies prof. \u0160\u00e1rka Posp\u00ed\u0161ilov\u00e1. 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