{"id":7157,"date":"2020-11-30T10:57:55","date_gmt":"2020-11-30T10:57:55","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=7157"},"modified":"2021-01-26T11:00:27","modified_gmt":"2021-01-26T11:00:27","slug":"targeting-casein-kinase-1-ck1-in-hematological-cancers","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/targeting-casein-kinase-1-ck1-in-hematological-cancers\/","title":{"rendered":"Targeting Casein Kinase 1 (CK1) in Hematological Cancers"},"content":{"rendered":"\n<p>The casein kinase 1 enzymes (CK1) form a family of serine\/threonine kinases with seven CK1 isoforms identified in humans. The most important substrates of CK1 kinases are proteins that act in the regulatory nodes essential for tumorigenesis of hematological malignancies. Among those, the most important are the functions of CK1s in the regulation of Wnt pathways, cell proliferation, apoptosis and autophagy.<\/p>\n<p>In this review, we summarize the recent developments in the understanding of biology and therapeutic potential of the inhibition of CK1 isoforms in the pathogenesis of chronic lymphocytic leukemia (CLL), other non-Hodgkin lymphomas (NHL), myelodysplastic syndrome (MDS), acute myeloid leukemia (AML) and multiple myeloma (MM).<\/p>\n<p>CK1\u03b4\/\u03b5 inhibitors block CLL development in preclinical models via inhibition of WNT-5A\/ROR1-driven non-canonical Wnt pathway. While no selective CK1 inhibitors have reached clinical stage to date, one dual PI3K\u03b4 and CK1\u03b5 inhibitor, umbralisib, is currently in clinical trials for CLL and NHL patients. In MDS, AML and MM, inhibition of CK1\u03b1, acting via activation of p53 pathway, showed promising preclinical activities and the first CK1\u03b1 inhibitor has now entered the clinical trials.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"479\" src=\"http:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/11\/cll_review_2-1024x479.jpg\" alt=\"\" class=\"wp-image-7160\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/11\/cll_review_2-1024x479.jpg 1024w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/11\/cll_review_2-300x140.jpg 300w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/11\/cll_review_2-768x359.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h5><strong>Authors:<\/strong><\/h5>\n<h5><strong>Pavl\u00edna Janovsk\u00e1<\/strong>, Emmanuel Normant, Hari Miskin and <strong>V\u00edt\u011bzslav Bryja<\/strong><\/h5>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns_515e81-08{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:flex-end;align-items:center;}.kt-btns_515e81-08 .kt-button{font-weight:normal;font-style:normal;}.kt-btns_515e81-08 .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns_515e81-08 .kt-btn-wrap-0 .kt-button{color:#fff;background:#009900;border-color:#fff;box-shadow:1px 1px 2px 3px rgba(0, 0, 0, 0.2);}.wp-block-kadence-advancedbtn.kt-btns_515e81-08 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_515e81-08 .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns_515e81-08 .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns_515e81-08 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_515e81-08 .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kt-btn-align-right kt-btn-tablet-align-inherit kt-btn-mobile-align-inherit kt-btns-wrap kt-btns_515e81-08\"><div class=\"kt-btn-wrap kt-btn-wrap-0\"><a class=\"kt-button kt-btn-0-action kt-btn-size-standard kt-btn-style-basic kt-btn-svg-show-always kt-btn-has-text-true kt-btn-has-svg-false\" href=\"https:\/\/www.mdpi.com\/1422-0067\/21\/23\/9026\"><span class=\"kt-btn-inner-text\">Read the whole story<\/span><\/a><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>The casein kinase 1 enzymes (CK1) form a family of serine\/threonine kinases with seven CK1 isoforms identified in humans. The most important substrates of CK1 kinases are proteins that act in the regulatory nodes essential for tumorigenesis of hematological malignancies. &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/targeting-casein-kinase-1-ck1-in-hematological-cancers\/\">Read More<\/a><\/p>\n","protected":false},"author":5,"featured_media":7165,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[252],"tags":[],"class_list":["post-7157","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nova-publikace"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Targeting Casein Kinase 1 (CK1) in Hematological Cancers - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/targeting-casein-kinase-1-ck1-in-hematological-cancers\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Targeting Casein Kinase 1 (CK1) in Hematological Cancers - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"The casein kinase 1 enzymes (CK1) form a family of serine\/threonine kinases with seven CK1 isoforms identified in humans. The most important substrates of CK1 kinases are proteins that act in the regulatory nodes essential for tumorigenesis of hematological malignancies. &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/targeting-casein-kinase-1-ck1-in-hematological-cancers\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Animal Physiology and Immunology\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-30T10:57:55+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-01-26T11:00:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/11\/ck1_cover.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1004\" \/>\n\t<meta property=\"og:image:height\" content=\"778\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Lucie Nesvadbov\u00e1\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lucie Nesvadbov\u00e1\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/targeting-casein-kinase-1-ck1-in-hematological-cancers\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/targeting-casein-kinase-1-ck1-in-hematological-cancers\/\"},\"author\":{\"name\":\"Lucie Nesvadbov\u00e1\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/3119766c8e4c78f08bbbde220469aee6\"},\"headline\":\"Targeting Casein Kinase 1 (CK1) in Hematological Cancers\",\"datePublished\":\"2020-11-30T10:57:55+00:00\",\"dateModified\":\"2021-01-26T11:00:27+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/targeting-casein-kinase-1-ck1-in-hematological-cancers\/\"},\"wordCount\":207,\"publisher\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/targeting-casein-kinase-1-ck1-in-hematological-cancers\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/11\/ck1_cover.jpg\",\"articleSection\":[\"Nov\u00e1 publikace\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/targeting-casein-kinase-1-ck1-in-hematological-cancers\/\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/targeting-casein-kinase-1-ck1-in-hematological-cancers\/\",\"name\":\"Targeting Casein Kinase 1 (CK1) in Hematological Cancers - 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