{"id":7155,"date":"2020-11-30T10:50:25","date_gmt":"2020-11-30T10:50:25","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=7155"},"modified":"2020-11-30T10:50:26","modified_gmt":"2020-11-30T10:50:26","slug":"a-clearance-period-after-soluble-lead-nanoparticle-inhalation-did-not-ameliorate-the-negative-effects-on-target-tissues-due-to-decreased-immune-response-2","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-clearance-period-after-soluble-lead-nanoparticle-inhalation-did-not-ameliorate-the-negative-effects-on-target-tissues-due-to-decreased-immune-response-2\/","title":{"rendered":"A Clearance Period after Soluble Lead Nanoparticle Inhalation Did Not Ameliorate the Negative Effects on Target Tissues Due to Decreased Immune Response"},"content":{"rendered":"\n<p>The inhalation of metal (including lead) nanoparticles poses a real health issue to people and animals living in polluted and\/or industrial areas.<\/p>\n<p>In this study, we exposed mice to lead(II) nitrate nanoparticles [Pb(NO<sub>3<\/sub>)<sub>2<\/sub> NPs], which represent a highly soluble form of lead, by inhalation. We aimed to uncover the effects of their exposure on individual target organs and to reveal potential variability in the lead clearance.<\/p>\n<p>We examined<\/p>\n<ul>\n<li><strong>(i)<\/strong> lead biodistribution in target organs using laser ablation and inductively coupled plasma mass spectrometry (LA-ICP-MS) and atomic absorption spectrometry (AAS),<\/li>\n<li><strong>(ii)<\/strong> lead effect on histopathological changes and immune cells response in secondary target organs and<\/li>\n<li><strong>(iii)<\/strong> the clearance ability of target organs. In the lungs and liver, Pb(NO<sub>3<\/sub>)<sub>2<\/sub> NP inhalation induced serious structural changes and their damage was present even after a 5-week clearance period despite the lead having been almost completely eliminated from the tissues.<\/li>\n<\/ul>\n<p>The numbers of macrophages significantly decreased after 11-week Pb(NO<sub>3<\/sub>)<sub>2<\/sub> NP inhalation; conversely, abundance of alpha-smooth muscle actin (\u03b1-SMA)-positive cells, which are responsible for augmented collagen production, increased in both tissues. Moreover, the expression of nuclear factor \u03baB (<span class=\"html-italic\">NF-\u03baB<\/span>) and selected cytokines, such as tumor necrosis factor alpha (<span class=\"html-italic\">TNF\u03b1<\/span>), transforming growth factor beta 1 (<span class=\"html-italic\">TGF\u03b21<\/span>), interleukin 6(<span class=\"html-italic\">IL-6<\/span>), <span class=\"html-italic\">IL-1\u03b1<\/span> and <span class=\"html-italic\">IL-1\u03b2<\/span> , displayed a tissue-specific response to lead exposure.<\/p>\n<p>In summary, diminished inflammatory response in tissues after Pb(NO<sub>3<\/sub>)<sub>2<\/sub> NPs inhalation was associated with prolonged negative effect of lead on tissues, as demonstrated by sustained pathological changes in target organs, even after long clearance period.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"751\" src=\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/11\/Pb_clanek-1024x751.jpg\" alt=\"\" class=\"wp-image-7150\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/11\/Pb_clanek-1024x751.jpg 1024w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/11\/Pb_clanek-300x220.jpg 300w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/11\/Pb_clanek-768x563.jpg 768w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/11\/Pb_clanek-848x622.jpg 848w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/11\/Pb_clanek-560x411.jpg 560w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/11\/Pb_clanek-740x542.jpg 740w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/11\/Pb_clanek-370x271.jpg 370w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/11\/Pb_clanek.jpg 1129w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption> <br> <br> <br> <strong>The effect of Pb(NO<\/strong><sub><strong>3<\/strong><\/sub><strong>)<\/strong><sub><strong>2<\/strong><\/sub><strong> NP inhalation and its clearance on the kidney. <\/strong><br> <strong>(A)<\/strong> Distribution of Pb in kidney samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) after Pb(NO<sub>3<\/sub>)<sub>2<\/sub> NP inhalation. The control kidney was without Pb positivity, Pb was detected in kidney cortex (co) after Pb(NO<sub>3<\/sub>)<sub>2<\/sub> NP inhalation but not in the medulla (me). After a 5-week clearance period, Pb was still present in kidney cortex. The graph of Pb level in the kidney at designated time points. <br><strong> (B)<\/strong> Distribution of Ca in kidney samples using LA-ICP-MS after Pb(NO<sub>3<\/sub>)<sub>2<\/sub> NP inhalation. The map of Ca exhibited higher distribution in kidney in Pb\/cl group compared with the control and Pb(NO<sub>3<\/sub>)<sub>2<\/sub> NP group. The graph of Ca level in the kidney at designated time points. Kidney Ca was significantly decreased after 2-week Pb(NO<sub>3<\/sub>)<sub>2<\/sub> NP inhalation (* p<br> &lt; 0.05) compared with the corresponding control group (ctr) and significantly increased in Pb\/cl group (\u2020 p<br> &lt; 0.05) compared with the corresponding Pb(NO<sub>3<\/sub>)<sub>2<\/sub> NP group. <br><strong> (C) <\/strong>Analysis of kidney ultrastructure in the transmission electron microscope (TEM).  <\/figcaption><\/figure>\n\n\n\n<h5><strong>Authors:<\/strong><\/h5>\n<h5>Dumkova J, Smutn\u00e1 T, Vrlikova L, Docekal B, <strong>Kristekova D<\/strong>, Vecera Z, Husakova Z, Jakesova V, Jedlickova A, Mikuska P, Capka L, Coufalik P, Tvrdonova M, Krumal K, Vaculovic T, Kanicky V, Hampl A, <strong>Buchtova M<\/strong><\/h5>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns_ae574f-2f{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:flex-end;align-items:center;}.kt-btns_ae574f-2f .kt-button{font-weight:normal;font-style:normal;}.kt-btns_ae574f-2f .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns_ae574f-2f .kt-btn-wrap-0 .kt-button{color:#fff;background:#009900;border-color:#fff;box-shadow:1px 1px 2px 3px rgba(0, 0, 0, 0.2);}.wp-block-kadence-advancedbtn.kt-btns_ae574f-2f .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_ae574f-2f .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns_ae574f-2f .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns_ae574f-2f .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_ae574f-2f .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kt-btn-align-right kt-btn-tablet-align-inherit kt-btn-mobile-align-inherit kt-btns-wrap kt-btns_ae574f-2f\"><div class=\"kt-btn-wrap kt-btn-wrap-0\"><a class=\"kt-button kt-btn-0-action kt-btn-size-standard kt-btn-style-basic kt-btn-svg-show-always kt-btn-has-text-true kt-btn-has-svg-false\" href=\"https:\/\/www.mdpi.com\/1422-0067\/21\/22\/8738\"><span class=\"kt-btn-inner-text\">Read the whole story<\/span><\/a><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>The inhalation of metal (including lead) nanoparticles poses a real health issue to people and animals living in polluted and\/or industrial areas. In this study, we exposed mice to lead(II) nitrate nanoparticles [Pb(NO3)2 NPs], which represent a highly soluble form &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-clearance-period-after-soluble-lead-nanoparticle-inhalation-did-not-ameliorate-the-negative-effects-on-target-tissues-due-to-decreased-immune-response-2\/\">Read More<\/a><\/p>\n","protected":false},"author":5,"featured_media":7150,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[256],"tags":[322],"class_list":["post-7155","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-new-paper","tag-buchtova-lab-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A Clearance Period after Soluble Lead Nanoparticle Inhalation Did Not Ameliorate the Negative Effects on Target Tissues Due to Decreased Immune Response - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-clearance-period-after-soluble-lead-nanoparticle-inhalation-did-not-ameliorate-the-negative-effects-on-target-tissues-due-to-decreased-immune-response-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Clearance Period after Soluble Lead Nanoparticle Inhalation Did Not Ameliorate the Negative Effects on Target Tissues Due to Decreased Immune Response - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"The inhalation of metal (including lead) nanoparticles poses a real health issue to people and animals living in polluted and\/or industrial areas. 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In this study, we exposed mice to lead(II) nitrate nanoparticles [Pb(NO3)2 NPs], which represent a highly soluble form &hellip; Read More","og_url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-clearance-period-after-soluble-lead-nanoparticle-inhalation-did-not-ameliorate-the-negative-effects-on-target-tissues-due-to-decreased-immune-response-2\/","og_site_name":"Department of Animal Physiology and Immunology","article_published_time":"2020-11-30T10:50:25+00:00","article_modified_time":"2020-11-30T10:50:26+00:00","og_image":[{"width":1129,"height":828,"url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/11\/Pb_clanek.jpg","type":"image\/jpeg"}],"author":"Lucie Nesvadbov\u00e1","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Lucie Nesvadbov\u00e1","Est. reading time":"2 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