{"id":5932,"date":"2020-07-14T06:13:03","date_gmt":"2020-07-14T06:13:03","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=5932"},"modified":"2020-07-14T06:13:05","modified_gmt":"2020-07-14T06:13:05","slug":"heptabladed-%ce%b2%e2%80%90propeller-lectins-pll2-and-phl-from-photorhabdus-spp-recognize-o%e2%80%90methylated-sugars-and-influence-the-host-immune-system","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/heptabladed-%ce%b2%e2%80%90propeller-lectins-pll2-and-phl-from-photorhabdus-spp-recognize-o%e2%80%90methylated-sugars-and-influence-the-host-immune-system\/","title":{"rendered":"Heptabladed \u03b2\u2010propeller lectins PLL2 and PHL from Photorhabdus spp. recognize O\u2010methylated sugars and influence the host immune system"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"769\" src=\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/07\/ph_clanek-1024x769.png\" alt=\"\" class=\"wp-image-5934\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/07\/ph_clanek-1024x769.png 1024w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/07\/ph_clanek-300x225.png 300w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/07\/ph_clanek-768x577.png 768w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/07\/ph_clanek-848x637.png 848w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/07\/ph_clanek-560x420.png 560w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/07\/ph_clanek-740x556.png 740w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/07\/ph_clanek-370x278.png 370w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/07\/ph_clanek.png 1216w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p style=\"text-align: justify;\"><em>O<\/em>\u2010methylation is an unusual sugar modification with a function that is not fully understood. Given its occurrence and recognition by lectins involved in the immune response, methylated sugars were proposed to represent a conserved pathogen\u2010associated molecular pattern.<\/p>\n<p style=\"text-align: justify;\">We describe the interaction of <em>O<\/em>\u2010methylated saccharides with two \u03b2\u2010propeller lectins, the newly described PLL2 from the entomopathogenic bacterium <em>Photorhabdus laumondii<\/em>, and its homologue PHL from the related human pathogen <em>Photorhabdus asymbiotica<\/em>.<\/p>\n<p style=\"text-align: justify;\">The crystal structures of PLL2 and PHL revealed up to 10 out of 14 potential binding sites per protein subunit to be occupied with <em>O<\/em>\u2010methylated structures. The avidity effect strengthens the interaction by 4 orders of magnitude. PLL2 and PHL also interfere with the early immune response by modulating the production of reactive oxygen species and phenoloxidase activity. Since bacteria from <em>Photorhabdus <\/em> spp. have a complex life cycle involving pathogenicity towards different hosts, the involvement of PLL2 and PHL might contribute to the pathogen overcoming insect and human immune system defences in the early stages of infection.<\/p>\n\n\n\n<div style=\"height:32px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns_933a74-1d{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns_933a74-1d .kt-button{font-weight:normal;font-style:normal;}.kt-btns_933a74-1d .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns_933a74-1d .kt-btn-wrap-0 .kt-button{width:274px;color:#fff;background:#009900;border-color:#fff;box-shadow:1px 1px 2px 3px rgba(0, 0, 0, 0.2);}.wp-block-kadence-advancedbtn.kt-btns_933a74-1d .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_933a74-1d .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns_933a74-1d .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns_933a74-1d .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_933a74-1d .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kt-btn-align-center kt-btn-tablet-align-inherit kt-btn-mobile-align-inherit kt-btns-wrap kt-btns_933a74-1d\"><div class=\"kt-btn-wrap kt-btn-wrap-0\"><a class=\"kt-button kt-btn-0-action kt-btn-size-standard kt-btn-style-basic kt-btn-svg-show-always kt-btn-has-text-true kt-btn-has-svg-false\" href=\"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full\/10.1111\/febs.15457\"><span class=\"kt-btn-inner-text\">Read more<\/span><\/a><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>O\u2010methylation is an unusual sugar modification with a function that is not fully understood. Given its occurrence and recognition by lectins involved in the immune response, methylated sugars were proposed to represent a conserved pathogen\u2010associated molecular pattern. We describe the &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/heptabladed-%ce%b2%e2%80%90propeller-lectins-pll2-and-phl-from-photorhabdus-spp-recognize-o%e2%80%90methylated-sugars-and-influence-the-host-immune-system\/\">Read More<\/a><\/p>\n","protected":false},"author":5,"featured_media":5934,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[271,252],"tags":[],"class_list":["post-5932","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hyrsl-lab-cz","category-nova-publikace"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Heptabladed \u03b2\u2010propeller lectins PLL2 and PHL from Photorhabdus spp. recognize O\u2010methylated sugars and influence the host immune system - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/heptabladed-\u03b2\u2010propeller-lectins-pll2-and-phl-from-photorhabdus-spp-recognize-o\u2010methylated-sugars-and-influence-the-host-immune-system\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Heptabladed \u03b2\u2010propeller lectins PLL2 and PHL from Photorhabdus spp. recognize O\u2010methylated sugars and influence the host immune system - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"O\u2010methylation is an unusual sugar modification with a function that is not fully understood. Given its occurrence and recognition by lectins involved in the immune response, methylated sugars were proposed to represent a conserved pathogen\u2010associated molecular pattern. We describe the &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/heptabladed-\u03b2\u2010propeller-lectins-pll2-and-phl-from-photorhabdus-spp-recognize-o\u2010methylated-sugars-and-influence-the-host-immune-system\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Animal Physiology and Immunology\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-14T06:13:03+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-07-14T06:13:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/07\/ph_clanek.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1216\" \/>\n\t<meta property=\"og:image:height\" content=\"913\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Lucie Nesvadbov\u00e1\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lucie Nesvadbov\u00e1\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/heptabladed-%ce%b2%e2%80%90propeller-lectins-pll2-and-phl-from-photorhabdus-spp-recognize-o%e2%80%90methylated-sugars-and-influence-the-host-immune-system\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/heptabladed-%ce%b2%e2%80%90propeller-lectins-pll2-and-phl-from-photorhabdus-spp-recognize-o%e2%80%90methylated-sugars-and-influence-the-host-immune-system\/\"},\"author\":{\"name\":\"Lucie Nesvadbov\u00e1\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/3119766c8e4c78f08bbbde220469aee6\"},\"headline\":\"Heptabladed \u03b2\u2010propeller lectins PLL2 and PHL from Photorhabdus spp. recognize O\u2010methylated sugars and influence the host immune system\",\"datePublished\":\"2020-07-14T06:13:03+00:00\",\"dateModified\":\"2020-07-14T06:13:05+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/heptabladed-%ce%b2%e2%80%90propeller-lectins-pll2-and-phl-from-photorhabdus-spp-recognize-o%e2%80%90methylated-sugars-and-influence-the-host-immune-system\/\"},\"wordCount\":188,\"publisher\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/heptabladed-%ce%b2%e2%80%90propeller-lectins-pll2-and-phl-from-photorhabdus-spp-recognize-o%e2%80%90methylated-sugars-and-influence-the-host-immune-system\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/07\/ph_clanek.png\",\"articleSection\":[\"Hyr\u0161l Lab CZ\",\"Nov\u00e1 publikace\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/heptabladed-%ce%b2%e2%80%90propeller-lectins-pll2-and-phl-from-photorhabdus-spp-recognize-o%e2%80%90methylated-sugars-and-influence-the-host-immune-system\/\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/heptabladed-%ce%b2%e2%80%90propeller-lectins-pll2-and-phl-from-photorhabdus-spp-recognize-o%e2%80%90methylated-sugars-and-influence-the-host-immune-system\/\",\"name\":\"Heptabladed \u03b2\u2010propeller lectins PLL2 and PHL from Photorhabdus spp. recognize O\u2010methylated sugars and influence the host immune system - 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