{"id":5870,"date":"2020-06-25T08:47:30","date_gmt":"2020-06-25T08:47:30","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=5870"},"modified":"2020-06-25T08:48:51","modified_gmt":"2020-06-25T08:48:51","slug":"protease-associated-domain-of-rnf43-is-not-necessary-for-the-suppression-of-wnt-%ce%b2-catenin-signaling-in-human-cells","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/protease-associated-domain-of-rnf43-is-not-necessary-for-the-suppression-of-wnt-%ce%b2-catenin-signaling-in-human-cells\/","title":{"rendered":"Protease associated domain of RNF43 is not necessary for the suppression of Wnt\/\u03b2-catenin signaling in human cells"},"content":{"rendered":"\n<h5>Another paper out and another step closer to a better understanding of <a href=\"https:\/\/twitter.com\/hashtag\/RNF43?src=hashtag_click\">#RNF43<\/a> tumor <a href=\"https:\/\/twitter.com\/hashtag\/suppressor?src=hashtag_click\">#suppressor<\/a> action thanks to <a href=\"https:\/\/twitter.com\/TRadaszkiewicz\">Tomek Radaszkiewicz<\/a>!<\/h5>\n<p>&nbsp;<\/p>\n<h5 style=\"text-align: center;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32527265\/\"><strong>Protease associated domain of RNF43 is not necessary for the suppression of Wnt\/\u03b2-catenin signaling in human cells<\/strong><\/a><\/h5>\n<h5 style=\"text-align: center;\"><strong><em>Cell Commun Signal. <\/em><\/strong>2020 Jun 11;18(1):91. doi: 10.1186\/s12964-020-00559-0.<\/h5>\n<p>&nbsp;<\/p>\n\n\n\n<h5><em>See the video:<\/em><\/h5>\n\n\n<style>#kt-layout-id_35f5ac-dd > .kt-row-column-wrap{align-content:start;}:where(#kt-layout-id_35f5ac-dd > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}#kt-layout-id_35f5ac-dd > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var( --global-kb-row-default-top, 25px );padding-bottom:var( --global-kb-row-default-bottom, 25px );padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);}#kt-layout-id_35f5ac-dd > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}#kt-layout-id_35f5ac-dd > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr) minmax(0, 6fr) minmax(0, 1fr);}#kt-layout-id_35f5ac-dd > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){#kt-layout-id_35f5ac-dd > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 1024px){#kt-layout-id_35f5ac-dd > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr) minmax(0, 6fr) minmax(0, 1fr);}}@media all and (max-width: 767px){#kt-layout-id_35f5ac-dd > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}#kt-layout-id_35f5ac-dd > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style>\n<div class=\"wp-block-kadence-rowlayout alignnone\"><div id=\"kt-layout-id_35f5ac-dd\" class=\"kt-row-layout-inner  kt-layout-id_35f5ac-dd\"><div class=\"kt-row-column-wrap kt-has-3-columns kt-gutter-default kt-v-gutter-default kt-row-valign-top kt-row-layout-center-exwide kt-tab-layout-inherit kt-m-colapse-left-to-right kt-mobile-layout-row\"><style>.kadence-column_1cecea-6d > .kt-inside-inner-col{border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;}.kadence-column_1cecea-6d > .kt-inside-inner-col,.kadence-column_1cecea-6d > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column_1cecea-6d > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column_1cecea-6d > .kt-inside-inner-col{flex-direction:column;}.kadence-column_1cecea-6d > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column_1cecea-6d > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column_1cecea-6d{position:relative;}@media all and (max-width: 1024px){.kadence-column_1cecea-6d > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column_1cecea-6d > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column inner-column-1 kadence-column_1cecea-6d\"><div class=\"kt-inside-inner-col\">\n<p><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column_3a011f-4e > .kt-inside-inner-col{border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;}.kadence-column_3a011f-4e > .kt-inside-inner-col,.kadence-column_3a011f-4e > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column_3a011f-4e > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column_3a011f-4e > .kt-inside-inner-col{flex-direction:column;}.kadence-column_3a011f-4e > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column_3a011f-4e > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column_3a011f-4e{position:relative;}@media all and (max-width: 1024px){.kadence-column_3a011f-4e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column_3a011f-4e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column inner-column-2 kadence-column_3a011f-4e\"><div class=\"kt-inside-inner-col\">\n<p><iframe loading=\"lazy\" src=\"https:\/\/www.youtube.com\/embed\/_ulyaqbfldc\" width=\"560\" height=\"315\" frameborder=\"0\" align=\"center\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column_7a0c63-9c > .kt-inside-inner-col{border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;}.kadence-column_7a0c63-9c > .kt-inside-inner-col,.kadence-column_7a0c63-9c > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column_7a0c63-9c > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column_7a0c63-9c > .kt-inside-inner-col{flex-direction:column;}.kadence-column_7a0c63-9c > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column_7a0c63-9c > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column_7a0c63-9c{position:relative;}@media all and (max-width: 1024px){.kadence-column_7a0c63-9c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column_7a0c63-9c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column inner-column-3 kadence-column_7a0c63-9c\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n\n<h5><em>Graphic summary:<\/em><\/h5>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img loading=\"lazy\" decoding=\"async\" width=\"668\" height=\"300\" src=\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/06\/rnf43pic.png\" alt=\"\" class=\"wp-image-5871\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/06\/rnf43pic.png 668w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/06\/rnf43pic-300x135.png 300w\" sizes=\"auto, (max-width: 668px) 100vw, 668px\" \/><\/figure><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Another paper out and another step closer to a better understanding of #RNF43 tumor #suppressor action thanks to Tomek Radaszkiewicz! &nbsp; Protease associated domain of RNF43 is not necessary for the suppression of Wnt\/\u03b2-catenin signaling in human cells Cell Commun &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/protease-associated-domain-of-rnf43-is-not-necessary-for-the-suppression-of-wnt-%ce%b2-catenin-signaling-in-human-cells\/\">Read More<\/a><\/p>\n","protected":false},"author":5,"featured_media":5885,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[412],"tags":[304],"class_list":["post-5870","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bryjalab","tag-bryjalab"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Protease associated domain of RNF43 is not necessary for the suppression of Wnt\/\u03b2-catenin signaling in human cells - Department of Animal 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