{"id":5789,"date":"2020-06-05T12:06:30","date_gmt":"2020-06-05T12:06:30","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=5789"},"modified":"2020-06-05T12:06:32","modified_gmt":"2020-06-05T12:06:32","slug":"bioactive-excreted-secreted-products-of-entomopathogenic-nematode-heterorhabditis-bacteriophora-inhibit-the-phenoloxidase-activity-during-the-infection-2","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/bioactive-excreted-secreted-products-of-entomopathogenic-nematode-heterorhabditis-bacteriophora-inhibit-the-phenoloxidase-activity-during-the-infection-2\/","title":{"rendered":"Bioactive Excreted\/Secreted Products of Entomopathogenic Nematode Heterorhabditis bacteriophora Inhibit the Phenoloxidase Activity during the Infection"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"925\" src=\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/06\/phyrsl_clanek-1024x925.jpg\" alt=\"\" class=\"wp-image-5784\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/06\/phyrsl_clanek-1024x925.jpg 1024w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/06\/phyrsl_clanek-300x271.jpg 300w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/06\/phyrsl_clanek-768x694.jpg 768w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/06\/phyrsl_clanek-848x766.jpg 848w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/06\/phyrsl_clanek-560x506.jpg 560w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/06\/phyrsl_clanek-740x668.jpg 740w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/06\/phyrsl_clanek-370x334.jpg 370w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/06\/phyrsl_clanek.jpg 1059w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h5 style=\"text-align: right;\"><a href=\"https:\/\/www.mdpi.com\/2075-4450\/11\/6\/353\"><em>Insects<\/em> <b>2020<\/b>, <em>11<\/em>(6), 353; https:\/\/doi.org\/10.3390\/insects11060353<\/a><\/h5>\n\n\n\n<h5 style=\"text-align: justify;\">ABSTRACT: Entomopathogenic nematodes (EPNs) are efficient insect parasites, that are known for their mutualistic relationship with entomopathogenic bacteria and their use in biocontrol. EPNs produce bioactive molecules referred to as excreted\/secreted products (ESPs), which have come to the forefront in recent years because of their role in the process of host invasion and the modulation of its immune response.<\/h5>\n<h5 style=\"text-align: justify;\">In the present study, we confirmed the production of ESPs in the EPN <span class=\"html-italic\">Heterorhabditis bacteriophora<\/span>, and investigated their role in the modulation of the phenoloxidase cascade, one of the key components of the insect immune system. ESPs were isolated from 14- and 21-day-old infective juveniles of <span class=\"html-italic\">H. bacteriophora<\/span>, which were found to be more virulent than newly emerged nematodes, as was confirmed by mortality assays using <span class=\"html-italic\">Galleria mellonella<\/span> larvae. The isolated ESPs were further purified and screened for the phenoloxidase-inhibiting activity. In these products, a 38 kDa fraction of peptides was identified as the main candidate source of phenoloxidase-inhibiting compounds. This fraction was further analyzed by mass spectrometry and the de novo sequencing approach. Six peptide sequences were identified in this active ESP fraction, including proteins involved in ubiquitination and the regulation of a Toll pathway, for which a role in the regulation of insect immune response has been proposed in previous studies.<\/h5>\n<p> <\/p>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns_7b76b5-36{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns_7b76b5-36 .kt-button{font-weight:normal;font-style:normal;}.kt-btns_7b76b5-36 .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns_7b76b5-36 .kt-btn-wrap-0 .kt-button{width:295px;color:#fff;background:#009900;border-color:#fff;box-shadow:1px 1px 2px 3px rgba(0, 0, 0, 0.2);}.wp-block-kadence-advancedbtn.kt-btns_7b76b5-36 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_7b76b5-36 .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns_7b76b5-36 .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns_7b76b5-36 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_7b76b5-36 .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kt-btn-align-center kt-btn-tablet-align-inherit kt-btn-mobile-align-inherit kt-btns-wrap kt-btns_7b76b5-36\"><div class=\"kt-btn-wrap kt-btn-wrap-0\"><a class=\"kt-button kt-btn-0-action kt-btn-size-standard kt-btn-style-basic kt-btn-svg-show-always kt-btn-has-text-true kt-btn-has-svg-false\" href=\"https:\/\/www.mdpi.com\/2075-4450\/11\/6\/353\"><span class=\"kt-btn-inner-text\">Read more<\/span><\/a><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Insects 2020, 11(6), 353; https:\/\/doi.org\/10.3390\/insects11060353 ABSTRACT: Entomopathogenic nematodes (EPNs) are efficient insect parasites, that are known for their mutualistic relationship with entomopathogenic bacteria and their use in biocontrol. EPNs produce bioactive molecules referred to as excreted\/secreted products (ESPs), which have &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/bioactive-excreted-secreted-products-of-entomopathogenic-nematode-heterorhabditis-bacteriophora-inhibit-the-phenoloxidase-activity-during-the-infection-2\/\">Read More<\/a><\/p>\n","protected":false},"author":5,"featured_media":5784,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[273,256],"tags":[],"class_list":["post-5789","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hyrsl-lab-en","category-new-paper"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Bioactive Excreted\/Secreted Products of Entomopathogenic Nematode Heterorhabditis bacteriophora Inhibit the Phenoloxidase Activity during the Infection - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/bioactive-excreted-secreted-products-of-entomopathogenic-nematode-heterorhabditis-bacteriophora-inhibit-the-phenoloxidase-activity-during-the-infection-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bioactive Excreted\/Secreted Products of Entomopathogenic Nematode Heterorhabditis bacteriophora Inhibit the Phenoloxidase Activity during the Infection - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"Insects 2020, 11(6), 353; https:\/\/doi.org\/10.3390\/insects11060353 ABSTRACT: Entomopathogenic nematodes (EPNs) are efficient insect parasites, that are known for their mutualistic relationship with entomopathogenic bacteria and their use in biocontrol. EPNs produce bioactive molecules referred to as excreted\/secreted products (ESPs), which have &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/bioactive-excreted-secreted-products-of-entomopathogenic-nematode-heterorhabditis-bacteriophora-inhibit-the-phenoloxidase-activity-during-the-infection-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Animal Physiology and Immunology\" \/>\n<meta property=\"article:published_time\" content=\"2020-06-05T12:06:30+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-05T12:06:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/06\/phyrsl_clanek.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1059\" \/>\n\t<meta property=\"og:image:height\" content=\"957\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Lucie Nesvadbov\u00e1\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lucie Nesvadbov\u00e1\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/bioactive-excreted-secreted-products-of-entomopathogenic-nematode-heterorhabditis-bacteriophora-inhibit-the-phenoloxidase-activity-during-the-infection-2\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/bioactive-excreted-secreted-products-of-entomopathogenic-nematode-heterorhabditis-bacteriophora-inhibit-the-phenoloxidase-activity-during-the-infection-2\/\"},\"author\":{\"name\":\"Lucie Nesvadbov\u00e1\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/3119766c8e4c78f08bbbde220469aee6\"},\"headline\":\"Bioactive Excreted\/Secreted Products of Entomopathogenic Nematode Heterorhabditis bacteriophora Inhibit the Phenoloxidase Activity during the Infection\",\"datePublished\":\"2020-06-05T12:06:30+00:00\",\"dateModified\":\"2020-06-05T12:06:32+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/bioactive-excreted-secreted-products-of-entomopathogenic-nematode-heterorhabditis-bacteriophora-inhibit-the-phenoloxidase-activity-during-the-infection-2\/\"},\"wordCount\":235,\"publisher\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/bioactive-excreted-secreted-products-of-entomopathogenic-nematode-heterorhabditis-bacteriophora-inhibit-the-phenoloxidase-activity-during-the-infection-2\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/06\/phyrsl_clanek.jpg\",\"articleSection\":[\"Hyr\u0161l Lab EN\",\"New paper\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/bioactive-excreted-secreted-products-of-entomopathogenic-nematode-heterorhabditis-bacteriophora-inhibit-the-phenoloxidase-activity-during-the-infection-2\/\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/bioactive-excreted-secreted-products-of-entomopathogenic-nematode-heterorhabditis-bacteriophora-inhibit-the-phenoloxidase-activity-during-the-infection-2\/\",\"name\":\"Bioactive Excreted\/Secreted Products of Entomopathogenic Nematode Heterorhabditis bacteriophora Inhibit the Phenoloxidase Activity during the Infection - 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