{"id":5717,"date":"2020-05-28T07:06:32","date_gmt":"2020-05-28T07:06:32","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=5717"},"modified":"2020-05-28T07:13:13","modified_gmt":"2020-05-28T07:13:13","slug":"trio-interacts-with-dishevelled-2","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/trio-interacts-with-dishevelled-2\/","title":{"rendered":"The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1008\" height=\"757\" src=\"http:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/05\/trio_tweet.jpg\" alt=\"\" class=\"wp-image-5712\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/05\/trio_tweet.jpg 1008w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/05\/trio_tweet-300x225.jpg 300w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/05\/trio_tweet-768x577.jpg 768w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/05\/trio_tweet-560x421.jpg 560w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/05\/trio_tweet-848x637.jpg 848w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/05\/trio_tweet-740x556.jpg 740w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/05\/trio_tweet-370x278.jpg 370w\" sizes=\"auto, (max-width: 1008px) 100vw, 1008px\" \/><\/figure>\n\n\n\n<h5 style=\"text-align: right;\"><a href=\"https:\/\/dev.biologists.org\/content\/147\/10\/dev186338\"><span class=\"highwire-cite-metadata-journal-title highwire-cite-metadata\">Development <\/span><span class=\"highwire-cite-metadata-date highwire-cite-metadata\">2020 <\/span><span class=\"highwire-cite-metadata-volume highwire-cite-metadata\">147: <\/span><span class=\"highwire-cite-metadata-pages highwire-cite-metadata\">dev186338 <\/span><\/a><\/h5>\n\n\n\n<h5 style=\"text-align: justify;\"><strong>ABSTRACT:<\/strong> Directional migration during embryogenesis and tumor progression faces the challenge that numerous external signals need to converge to precisely control cell movement. The Rho guanine exchange factor (GEF) Trio is especially well suited to relay signals, as it features distinct catalytic domains to activate Rho GTPases. Here, we show that Trio is required for <em>Xenopus<\/em> cranial neural crest (NC) cell migration and cartilage formation. Trio cell-autonomously controls protrusion formation of NC cells and Trio morphant NC cells show a blebbing phenotype. Interestingly, the Trio GEF2 domain is sufficient to rescue protrusion formation and migration of Trio morphant NC cells. We show that this domain interacts with the DEP\/C-terminus of Dishevelled (DVL). DVL \u2013 but not a deletion construct lacking the DEP domain \u2013 is able to rescue protrusion formation and migration of Trio morphant NC cells. This is likely mediated by activation of Rac1, as we find that DVL rescues Rac1 activity in Trio morphant embryos. Thus, our data provide evidence for a novel signaling pathway, whereby Trio controls protrusion formation of cranial NC cells by interacting with DVL to activate Rac1.<\/h5>\n\n\n\n<h5 class=\"highwire-cite-authors\" style=\"text-align: center;\"><span class=\"highwire-citation-authors\"><span class=\"highwire-citation-author first has-tooltip hasTooltip author-popup-hover\" data-delta=\"0\" data-hasqtip=\"0\" aria-describedby=\"qtip-0\">Marie-Claire Kratzer<\/span>, <span class=\"highwire-citation-author has-tooltip hasTooltip\" data-delta=\"1\" data-hasqtip=\"1\" aria-describedby=\"qtip-1\">Sarah F. S. Becker<\/span>, <span class=\"highwire-citation-author\" data-delta=\"2\">Anita Grund<\/span>, <span class=\"highwire-citation-author\" data-delta=\"3\">Anne Merks<\/span>, <strong><span class=\"highwire-citation-author\" data-delta=\"4\">Jakub Harno\u0161<\/span><\/strong>, <strong><span class=\"highwire-citation-author\" data-delta=\"5\">V\u00edt\u011bzslav Bryja<\/span><\/strong>, <span class=\"highwire-citation-author\" data-delta=\"6\">Klaudia Giehl<\/span>, <span class=\"highwire-citation-author\" data-delta=\"7\">Jubin Kashef<\/span>, <span class=\"highwire-citation-author has-tooltip hasTooltip\" data-delta=\"8\" data-hasqtip=\"2\" aria-describedby=\"qtip-2\">Annette Borchers<\/span><\/span><\/h5>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns_72b29a-02{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns_72b29a-02 .kt-button{font-weight:normal;font-style:normal;}.kt-btns_72b29a-02 .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns_72b29a-02 .kt-btn-wrap-0 .kt-button{color:#fff;background:#009900;border-color:#fff;box-shadow:1px 1px 2px 3px rgba(0, 0, 0, 0.2);}.wp-block-kadence-advancedbtn.kt-btns_72b29a-02 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_72b29a-02 .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns_72b29a-02 .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns_72b29a-02 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_72b29a-02 .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kt-btn-align-center kt-btn-tablet-align-inherit kt-btn-mobile-align-inherit kt-btns-wrap kt-btns_72b29a-02\"><div class=\"kt-btn-wrap kt-btn-wrap-0\"><a class=\"kt-button kt-btn-0-action kt-btn-size-standard kt-btn-style-basic kt-btn-svg-show-always kt-btn-has-text-true kt-btn-has-svg-false\" href=\"https:\/\/dev.biologists.org\/content\/147\/10\/dev186338\"><span class=\"kt-btn-inner-text\">Read the whole story<\/span><\/a><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Development 2020 147: dev186338 ABSTRACT: Directional migration during embryogenesis and tumor progression faces the challenge that numerous external signals need to converge to precisely control cell movement. The Rho guanine exchange factor (GEF) Trio is especially well suited to relay &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/trio-interacts-with-dishevelled-2\/\">Read More<\/a><\/p>\n","protected":false},"author":5,"featured_media":5712,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[412,256],"tags":[304],"class_list":["post-5717","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bryjalab","category-new-paper","tag-bryjalab"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/trio-interacts-with-dishevelled-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"Development 2020 147: dev186338 ABSTRACT: Directional migration during embryogenesis and tumor progression faces the challenge that numerous external signals need to converge to precisely control cell movement. The Rho guanine exchange factor (GEF) Trio is especially well suited to relay &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/trio-interacts-with-dishevelled-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Animal Physiology and Immunology\" \/>\n<meta property=\"article:published_time\" content=\"2020-05-28T07:06:32+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-05-28T07:13:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/05\/trio_tweet.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1008\" \/>\n\t<meta property=\"og:image:height\" content=\"757\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Lucie Nesvadbov\u00e1\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lucie Nesvadbov\u00e1\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/trio-interacts-with-dishevelled-2\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/trio-interacts-with-dishevelled-2\/\"},\"author\":{\"name\":\"Lucie Nesvadbov\u00e1\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/3119766c8e4c78f08bbbde220469aee6\"},\"headline\":\"The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled\",\"datePublished\":\"2020-05-28T07:06:32+00:00\",\"dateModified\":\"2020-05-28T07:13:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/trio-interacts-with-dishevelled-2\/\"},\"wordCount\":228,\"publisher\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/trio-interacts-with-dishevelled-2\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/05\/trio_tweet.jpg\",\"keywords\":[\"Bryjalab\"],\"articleSection\":[\"Bryjalab\",\"New paper\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/trio-interacts-with-dishevelled-2\/\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/trio-interacts-with-dishevelled-2\/\",\"name\":\"The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled - 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