{"id":4412,"date":"2020-03-17T09:19:38","date_gmt":"2020-03-17T09:19:38","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=4412"},"modified":"2020-03-17T09:22:55","modified_gmt":"2020-03-17T09:22:55","slug":"variability-in-the-clearance-of-lead-oxide-nanoparticles-is-associated-with-alteration-of-specific-membrane-transporters-2","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/variability-in-the-clearance-of-lead-oxide-nanoparticles-is-associated-with-alteration-of-specific-membrane-transporters-2\/","title":{"rendered":"Variability in the Clearance of Lead Oxide Nanoparticles Is Associated with Alteration of Specific Membrane Transporters"},"content":{"rendered":"\n<p>Lead oxide nanoparticles (PbONPs), upon their entry into the lungs <i>via<\/i> inhalation, induce structural changes in primary and secondary target organs. The fate and ultrastructural localization of PbONPs in organs is known to be dependent on the specific organ. Here, we focused on the differences in the ability to clear the inhaled PbONPs from secondary target organs and on molecular and cellular mechanisms contributing to nanoparticle removal. Mice were exposed to PbONPs in whole-body inhalation chambers. Clearance of ionic lead and PbONPs (Pb\/PbONPs) from the lungs and liver was very effective, with the lead being almost completely eliminated from the lungs and the physiological state of the lung tissue conspicuously restored. Kidneys exposed to nanoparticles did not exhibit serious signs of damage; however, LA-ICP-MS uncovered a certain amount of lead located preferentially in the kidney cortex even after a clearance period. The concentration of lead in femurs, as representatives of the axial skeleton, was the highest among studied organs at all designated time points after PbONP exposure, and the clearance ability of lead from the femurs was very low in contrast to other organs. The organ-specific increase of ABC transporters expression (ABCG2 in lungs and ABCC3 in the liver) was observed in exposed animals, suggesting their involvement in removing Pb\/PbONPs from tissues. Moreover, the expression of <i>caveolins<\/i> and <i>clathrin<\/i> displayed a tissue-specific response to lead exposure. Our results uncovered high variability among the organs in their ability to clear Pb\/PbONPs and in the transporters involved in this process.<\/p>\n<p>Read the whole story <strong><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.9b08143\">HERE<\/a><\/strong>.<\/p>\n\n\n\n<p><strong><em>Authors:<\/em><\/strong><\/p>\n<p><em><strong>Jana Dumkova\u0301<\/strong>, <strong>Tereza Smutna\u0301<\/strong>, <strong>Lucie Vrl\u00edkova\u0301<\/strong>, Hana Kotasova\u0301, Bohumil Doc\u030cekal, Luka\u0301s\u030c C\u030capka, <\/em><em>Michaela Tvrdon\u030cova\u0301, <strong>Veronika Jakes\u030cova\u0301<\/strong>, Vendula Pelkova\u0301, Kamil Kr\u030cu\u030amal, Pavel Coufal\u00edk, Pavel Mikus\u030cka, <\/em><em>Zbyne\u030ck Vec\u030cer\u030ca, Toma\u0301s\u030c Vaculovic\u030c, Zuzana Husa\u0301kova\u0301, Viktor Kanicky\u0301, Ales\u030c Hampl, <\/em><em>and <strong>Marcela Buchtova\u0301<\/strong><\/em><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"999\" height=\"562\" src=\"http:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/03\/marci_pub_200317.jpeg\" alt=\"\" class=\"wp-image-4404\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/03\/marci_pub_200317.jpeg 999w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/03\/marci_pub_200317-300x169.jpeg 300w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/03\/marci_pub_200317-768x432.jpeg 768w\" sizes=\"auto, (max-width: 999px) 100vw, 999px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Lead oxide nanoparticles (PbONPs), upon their entry into the lungs via inhalation, induce structural changes in primary and secondary target organs. The fate and ultrastructural localization of PbONPs in organs is known to be dependent on the specific organ. Here, &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/variability-in-the-clearance-of-lead-oxide-nanoparticles-is-associated-with-alteration-of-specific-membrane-transporters-2\/\">Read More<\/a><\/p>\n","protected":false},"author":5,"featured_media":4411,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[256],"tags":[322],"class_list":["post-4412","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-new-paper","tag-buchtova-lab-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Variability in the Clearance of Lead Oxide Nanoparticles Is Associated with Alteration of Specific Membrane Transporters - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/variability-in-the-clearance-of-lead-oxide-nanoparticles-is-associated-with-alteration-of-specific-membrane-transporters-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Variability in the Clearance of Lead Oxide Nanoparticles Is Associated with Alteration of Specific Membrane Transporters - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"Lead oxide nanoparticles (PbONPs), upon their entry into the lungs via inhalation, induce structural changes in primary and secondary target organs. The fate and ultrastructural localization of PbONPs in organs is known to be dependent on the specific organ. Here, &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/variability-in-the-clearance-of-lead-oxide-nanoparticles-is-associated-with-alteration-of-specific-membrane-transporters-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Animal Physiology and Immunology\" \/>\n<meta property=\"article:published_time\" content=\"2020-03-17T09:19:38+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-03-17T09:22:55+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/03\/marci_pub_200317_2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"704\" \/>\n\t<meta property=\"og:image:height\" content=\"566\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Lucie Nesvadbov\u00e1\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lucie Nesvadbov\u00e1\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/variability-in-the-clearance-of-lead-oxide-nanoparticles-is-associated-with-alteration-of-specific-membrane-transporters-2\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/variability-in-the-clearance-of-lead-oxide-nanoparticles-is-associated-with-alteration-of-specific-membrane-transporters-2\/\"},\"author\":{\"name\":\"Lucie Nesvadbov\u00e1\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/3119766c8e4c78f08bbbde220469aee6\"},\"headline\":\"Variability in the Clearance of Lead Oxide Nanoparticles Is Associated with Alteration of Specific Membrane Transporters\",\"datePublished\":\"2020-03-17T09:19:38+00:00\",\"dateModified\":\"2020-03-17T09:22:55+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/variability-in-the-clearance-of-lead-oxide-nanoparticles-is-associated-with-alteration-of-specific-membrane-transporters-2\/\"},\"wordCount\":325,\"publisher\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/variability-in-the-clearance-of-lead-oxide-nanoparticles-is-associated-with-alteration-of-specific-membrane-transporters-2\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/03\/marci_pub_200317_2.jpg\",\"keywords\":[\"Buchtova Lab-EN\"],\"articleSection\":[\"New paper\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/variability-in-the-clearance-of-lead-oxide-nanoparticles-is-associated-with-alteration-of-specific-membrane-transporters-2\/\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/variability-in-the-clearance-of-lead-oxide-nanoparticles-is-associated-with-alteration-of-specific-membrane-transporters-2\/\",\"name\":\"Variability in the Clearance of Lead Oxide Nanoparticles Is Associated with Alteration of Specific Membrane Transporters - 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The fate and ultrastructural localization of PbONPs in organs is known to be dependent on the specific organ. Here, &hellip; Read More","og_url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/variability-in-the-clearance-of-lead-oxide-nanoparticles-is-associated-with-alteration-of-specific-membrane-transporters-2\/","og_site_name":"Department of Animal Physiology and Immunology","article_published_time":"2020-03-17T09:19:38+00:00","article_modified_time":"2020-03-17T09:22:55+00:00","og_image":[{"width":704,"height":566,"url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2020\/03\/marci_pub_200317_2.jpg","type":"image\/jpeg"}],"author":"Lucie Nesvadbov\u00e1","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Lucie Nesvadbov\u00e1","Est. reading time":"2 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