Deadline p\u0159ihl\u00e1\u0161ek: 22. 4. 2025. <\/p>\n\n\n\n
Pro podrobnosti je mo\u017eno neform\u00e1ln\u011b kontaktovat na\u0161i absolventku na m\u00edst\u011b Marii \u0160ulcovou.<\/p>\n\n\n\n
How Regulatory DNA and Epigenetics Rewired Human Brain Development<\/strong><\/p>\n\n\n\n We are seeking a highly motivated PhD student to join our project on understanding how human-specific genetic and epigenetic changes have shaped the development and function of our brains. The project aims to uncover the molecular mechanisms by which non-coding regulatory elements influence brain development, evolution and contributes to higher cognitive abilities. We will employ cutting-edge single-cell and spatial epigenomic technologies, combined with in vitro brain organoid models of both human and non-human primates, to identify and functionally characterize species-specific regulatory elements. By perturbing these candidate elements through CRISPR-based genome editing, we seek to reveal their impact on neuronal development, connectivity, and activity. This research has implications for understanding what makes the human brain unique, as well as for shedding light on neurodevelopmental disorders such as autism and schizophrenia.<\/p>\n\n\n\n The ideal candidate should have background in molecular and cellular biology with hands-on experience in one or more of the following areas:<\/strong><\/p>\n\n\n\n