Ve st\u0159edu 5. \u00fanora prob\u011bhl PhD Workshop. Akce je d\u016fle\u017eitou a povinnou sou\u010d\u00e1st\u00ed doktorsk\u00e9ho studia. Studenti 2. ro\u010dn\u00edku p\u0159ed publikem prezentuj\u00ed anglicky sv\u016fj projekt, v\u011bdeck\u00e9 hypot\u00e9zy, dosavadn\u00ed pokrok a pl\u00e1ny do budoucna. D\u00edky zp\u011btn\u00e9 vazb\u011b od odborn\u00e9ho publika mohou studenti v\u010das p\u0159edej\u00edt mo\u017en\u00fdm probl\u00e9m\u016fm. <\/p>\n\n\n\n
Prvn\u00ed vystupuj\u00edc\u00ed byla Mgr. Krist\u00edna Briedikov\u00e1<\/strong> s t\u00e9matem Evolution of insect circadian clock and its sensitivity to magnetic fields. Tento projekt zkoum\u00e1 funk\u010dn\u00ed roli gen\u016f cirkadi\u00e1nn\u00edch hodin u hmyzu pomoc\u00ed RNA interference, Krist\u00edna sleduje jejich vliv na rytmick\u00e9 chov\u00e1n\u00ed nap\u0159\u00ed\u010d druhy. D\u00e1le se zam\u011b\u0159uje na roli sav\u010d\u00edho kryptochromu v magnetosenzitivit\u011b a testuje, jak elektromagnetick\u00e1 pole ovliv\u0148uj\u00ed vnit\u0159n\u00ed hodiny hmyzu. Druhou vystupuj\u00edc\u00ed byla Mgr. \u0160\u00e1rka Hrachovinov\u00e1<\/strong> s t\u00e9matem Diagnostic and Prognostic Potential of Malignant Ascites for Ovarian Cancer Research. Tento projekt se zam\u011b\u0159uje na extracelul\u00e1rn\u00ed vezikuly v ascitu jako mo\u017en\u00fd zdroj prognostick\u00fdch a prediktivn\u00edch biomarker\u016f pro high-grade ser\u00f3zn\u00ed karcinom vaje\u010dn\u00edk\u016f. Optimalizac\u00ed metod izolace EV a roz\u0161\u00ed\u0159en\u00edm anal\u00fdzy biomarker\u016f si v\u00fdzkum klade za c\u00edl zlep\u0161it v\u010dasnou diagnostiku a l\u00e9\u010debn\u00e9 strategie pro pacientky s rakovinou vaje\u010dn\u00edk\u016f. T\u00e9matu se v\u011bnuje ve skupin\u011b<\/a> dr. Venduly Posp\u00edchalov\u00e9.<\/p>\n\n\n\n T\u0159et\u00ed vystupuj\u00edc\u00ed byla Mgr. Eli\u0161ka Kramn\u00e1<\/strong> s t\u00e9matem Regulation of proliferation in cardiomyogenesis. Tento projekt zkoum\u00e1 regulaci proliferace kardiomyocyt\u016f b\u011bhem jejich diferenciace z pluripotentn\u00edch kmenov\u00fdch bun\u011bk s c\u00edlem zlep\u0161it strategie srde\u010dn\u00ed regenerace. Anal\u00fdzou dynamiky bun\u011b\u010dn\u00e9ho cyklu a testov\u00e1n\u00edm pro-proliferativn\u00edch faktor\u016f, v\u010detn\u011b sign\u00e1ln\u00ed dr\u00e1hy ERK\/DUSP6, se v\u00fdzkum zam\u011b\u0159uje na zv\u00fd\u0161en\u00ed produkce kardiomyocyt\u016f pro regenerativn\u00ed medic\u00ednu. Projekt vznik\u00e1 v laborato\u0159i<\/a> dr. Ji\u0159\u00edho Pachern\u00edka.<\/p>\n\n\n\n \u010ctvrt\u00fdm vystupuj\u00edc\u00edm byla Mgr. Barbora Li\u0161kov\u00e1<\/strong> s t\u00e9matem Developmental Insights into Phenylalanine and Tyrosine Metabolic Diseases). Tento projekt vyu\u017e\u00edv\u00e1 ryb\u00ed model dania pruhovan\u00e9ho ke studiu patogeneze alkaptonurie a dlouhodob\u00fdch \u00fa\u010dink\u016f l\u00e9\u010dby nitisinonem. D\u00edky pokro\u010dil\u00fdm zobrazovac\u00edm a analytick\u00fdm metod\u00e1m se v\u00fdzkum zam\u011b\u0159uje na optimalizaci l\u00e9\u010debn\u00fdch strategi\u00ed a z\u00edsk\u00e1n\u00ed nov\u00fdch poznatk\u016f o pr\u016fb\u011bhu a l\u00e9\u010db\u011b tohoto metabolick\u00e9ho onemocn\u011bn\u00ed. T\u00e9ma zpracov\u00e1v\u00e1 v laborato\u0159i<\/a> dr. Petera Fabiana.<\/p>\n\n\n\n P\u00e1t\u00fdm vystupuj\u00edc\u00edm byl Ziyaurrahman Marhama Sirajudheen<\/strong> s t\u00e9matem Decoding the skeletal stem cell niche identity and its function in skeletal homeostasis. Projekt zkoum\u00e1 roli nov\u00e9 populace derm\u00e1ln\u00edch fibroblast\u016f v niche kostn\u00edch kmenov\u00fdch bun\u011bk p\u0159i udr\u017eov\u00e1n\u00ed zdrav\u00ed kost\u00ed prost\u0159ednictv\u00edm metabolick\u00e9 regulace. Pomoc\u00ed sledov\u00e1n\u00ed bun\u011b\u010dn\u00fdch lini\u00ed a genetick\u00fdch n\u00e1stroj\u016f na modelov\u00e9m druhu dania pruhovan\u00e9ho se v\u00fdzkum zam\u011b\u0159uje na definov\u00e1n\u00ed jejich funkce, sleduje vliv na udr\u017eov\u00e1n\u00ed SSC a jejich ochrannou roli v prevenci akumulace toxick\u00fdch metabolit\u016f u kostn\u00edch poruch. Ziya pracuje tak\u00e9 v laborato\u0159i<\/a> dr. Petera Fabiana.<\/p>\n\n\n\n \u0160est\u00fdm vystupuj\u00edc\u00edm byla Mgr. Zuzana Tom\u00e1\u0161ikov\u00e1<\/strong> s t\u00e9matem The immune system driven alterations in 3D gut organoid – a model of sepsis-associated patholog. Tento projekt zkoum\u00e1, jak imunitn\u00ed dysregulace p\u0159isp\u00edv\u00e1 k dysfunkci slizni\u010dn\u00ed tk\u00e1n\u011b p\u0159i sepsi a eosinofiln\u00ed ezofagitid\u011b se zam\u011b\u0159en\u00edm na remodulaci tk\u00e1n\u011b a fibr\u00f3zu. Pou\u017eit\u00edm 3D model\u016f a imunitn\u00edho profilov\u00e1n\u00ed v\u00fdzkum usiluje o pochopen\u00ed toho, jak z\u00e1n\u011bt naru\u0161uje integritu slizni\u010dn\u00ed bari\u00e9ry a p\u0159isp\u00edv\u00e1 k progresi onemocn\u011bn\u00ed u obou stav\u016f. Zuzana se t\u00e9matu se v\u011bnuje v laborato\u0159i<\/a> dr. Jana Fri\u010de.<\/p>\n\n\n\n Posledn\u00edm vystupuj\u00edc\u00edm byl Mgr. David Zim\u010d\u00edk<\/strong> s t\u00e9matem SATB2 as a master regulator of cells producing hard tissues. Tento projekt zkoum\u00e1 kritickou roli SATB2 ve v\u00fdvoji kraniofaci\u00e1ln\u00edch struktur pomoc\u00ed modelu my\u0161\u00ed s deficitem Satb2. N\u00e1sledky deficitu jsou r\u016fzn\u00e9 abnormality jako roz\u0161t\u011bp patra, hypoplazie doln\u00ed \u010delisti a zpo\u017ed\u011bn\u00ed ve v\u00fdvoji kost\u00ed. V\u00fdzkum se zam\u011b\u0159uje na pochopen\u00ed mechanism\u016f, jak SATB2 ovliv\u0148uje degradaci Meckelovy chrupavky a osifikaci doln\u00ed \u010delisti, co\u017e osv\u011btl\u00ed jeho \u0161ir\u0161\u00ed vliv na kraniofaci\u00e1ln\u00ed v\u00fdvoj. T\u00e9ma zpracov\u00e1v\u00e1 v laborato\u0159i<\/a> prof. Marcely Buchtov\u00e9.<\/p>\n\n\n
T\u00e9matu se v\u011bnuje v laborato\u0159i<\/a> doc. Martina V\u00e1chy. <\/p>\n\n\n\n