{"id":12453,"date":"2024-11-20T08:28:58","date_gmt":"2024-11-20T08:28:58","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=12453"},"modified":"2024-11-20T08:29:00","modified_gmt":"2024-11-20T08:29:00","slug":"linking-planar-polarity-signalling-to-actomyosin-contractility-during-vertebrate-neurulation","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/linking-planar-polarity-signalling-to-actomyosin-contractility-during-vertebrate-neurulation\/","title":{"rendered":"Linking planar polarity signalling to actomyosin contractility during vertebrate neurulation"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"315\" src=\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/11\/rsob.240251.f007-1024x315.jpg\" alt=\"\" class=\"wp-image-12454\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/11\/rsob.240251.f007-1024x315.jpg 1024w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/11\/rsob.240251.f007-300x92.jpg 300w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/11\/rsob.240251.f007-768x237.jpg 768w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/11\/rsob.240251.f007-740x228.jpg 740w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/11\/rsob.240251.f007-370x114.jpg 370w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/11\/rsob.240251.f007-848x261.jpg 848w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/11\/rsob.240251.f007.jpg 1656w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption> <br>A suggested mechanism of PCP-dependent  activation of cell contractility through the binding of cytoplasmic PCP proteins prickle (Pk), dishevelled (Dvl) and casein kinase 1\u03b5 (CK1) to actomyosin proteins Rap1GAP2 and myosin light chain (MLC), leading to its phosphorylation (pMLC) through Rap1. This model is based on our experimental data in MDCK cells and in the neural plate of <em>Xenopus<\/em>  embryos. We suggest that the key event in this process is the right balance of pMLC levels, which are regulated by cytoplasmic PCP proteins.   <\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"d10535680e1\"><strong>Abstract<\/strong><\/h3>\n\n\n\n<p>Actomyosin contractility represents an ancient feature of eukaryotic cells participating in many developmental and homeostasis events, including tissue morphogenesis, muscle contraction and cell migration, with dysregulation implicated in various pathological conditions, such as cancer. At the molecular level, actomyosin comprises actin bundles and myosin motor proteins that are sensitive to posttranslational  modifications like phosphorylation. While the molecular components of  actomyosin are well understood, the coordination of contractility by extracellular and intracellular signals, particularly from cellular signalling pathways, remains incompletely elucidated. <\/p>\n\n\n\n<p><strong>This study focuses on WNT\/planar cell polarity (PCP) signalling, previously associated  with actomyosin contractility during vertebrate neurulation. Our investigation reveals that the main cytoplasmic PCP proteins, Prickle and Dishevelled, interact with key actomyosin components such as myosin light chain 9 (MLC9), leading to its phosphorylation and localized activation.<\/strong> Using proteomics and microscopy approaches, we demonstrate  that both PCP proteins actively control actomyosin contractility through Rap1 small GTPases in relevant <em>in vitro<\/em> and <em>in vivo<\/em>  models. These findings unveil a novel mechanism of how PCP signalling regulates actomyosin contractility through MLC9 and Rap1 that is relevant to vertebrate neurulation.<\/p>\n\n\n<style>.wp-block-kadence-advancedheading.kt-adv-heading_465065-64, .wp-block-kadence-advancedheading.kt-adv-heading_465065-64[data-kb-block=\"kb-adv-heading_465065-64\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading_465065-64 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading_465065-64[data-kb-block=\"kb-adv-heading_465065-64\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}<\/style>\n<h3 id=\"kt-adv-heading_465065-64\" class=\"kt-adv-heading_465065-64 wp-block-kadence-advancedheading\"><strong>Authors<\/strong><\/h3>\n\n\n\n<p> <strong>Sarka Novotna<\/strong>, <strong>Lorena Agostini Maia<\/strong>, <strong>Katarzyna Anna Radaszkiewicz<\/strong>, Pavel Roudnicky and <strong>Jakub Harnos<\/strong><\/p>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns_637631-99{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:flex-start;align-items:center;}.kt-btns_637631-99 .kt-button{font-weight:normal;font-style:normal;}.kt-btns_637631-99 .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns_637631-99 .kt-btn-wrap-0 .kt-button{color:#fff;background:#009900;border-color:#555555;}.wp-block-kadence-advancedbtn.kt-btns_637631-99 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_637631-99 .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns_637631-99 .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns_637631-99 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_637631-99 .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kt-btn-align-left kt-btn-tablet-align-inherit kt-btn-mobile-align-inherit kt-btns-wrap kt-btns_637631-99\"><div class=\"kt-btn-wrap kt-btn-wrap-0\"><a class=\"kt-button kt-btn-0-action kt-btn-size-standard kt-btn-style-basic kt-btn-svg-show-always kt-btn-has-text-true kt-btn-has-svg-false\" href=\"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsob.240251\"><span class=\"kt-btn-inner-text\">Read the whole story<\/span><\/a><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Abstract Actomyosin contractility represents an ancient feature of eukaryotic cells participating in many developmental and homeostasis events, including tissue morphogenesis, muscle contraction and cell migration, with dysregulation implicated in various pathological conditions, such as cancer. At the molecular level, actomyosin &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/linking-planar-polarity-signalling-to-actomyosin-contractility-during-vertebrate-neurulation\/\">Read More<\/a><\/p>\n","protected":false},"author":10,"featured_media":12454,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[252],"tags":[],"class_list":["post-12453","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nova-publikace"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Linking planar polarity signalling to actomyosin contractility during vertebrate neurulation - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/linking-planar-polarity-signalling-to-actomyosin-contractility-during-vertebrate-neurulation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Linking planar polarity signalling to actomyosin contractility during vertebrate neurulation - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"Abstract Actomyosin contractility represents an ancient feature of eukaryotic cells participating in many developmental and homeostasis events, including tissue morphogenesis, muscle contraction and cell migration, with dysregulation implicated in various pathological conditions, such as cancer. 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