{"id":12320,"date":"2024-10-01T10:31:20","date_gmt":"2024-10-01T10:31:20","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=12320"},"modified":"2024-10-29T10:37:27","modified_gmt":"2024-10-29T10:37:27","slug":"carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/","title":{"rendered":"Carboxy-terminal polyglutamylation regulates signalling and phase separation of the Dishevelled protein"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"550\" height=\"398\" src=\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/10\/44318_2024_254_figa_html.jpg\" alt=\"\" class=\"wp-image-12321\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/10\/44318_2024_254_figa_html.jpg 550w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/10\/44318_2024_254_figa_html-300x217.jpg 300w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/10\/44318_2024_254_figa_html-370x268.jpg 370w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p>Polyglutamylation is a reversible posttranslational modification that is  catalyzed by enzymes of the tubulin tyrosine ligase-like (TTLL) family.  Here, we found that TTLL11 generates a previously unknown type of  polyglutamylation that is initiated by the addition of a glutamate  residue to the free C-terminal carboxyl group of a substrate protein.  TTLL11 efficiently polyglutamylates the Wnt signaling protein  Dishevelled 3 (DVL3), thereby changing the interactome of DVL3.  Polyglutamylation increases the capacity of DVL3 to get phosphorylated, to undergo phase separation, and to act in the noncanonical Wnt pathway.  Both carboxy-terminal polyglutamylation and the resulting reduction in  phase separation capacity of DVL3 can be reverted by the deglutamylating enzyme CCP6, demonstrating a causal relationship between  TTLL11-mediated polyglutamylation and phase separation. Thus, C-terminal polyglutamylation represents a new type of posttranslational  modification, broadening the range of proteins that can be modified by polyglutamylation and providing the first evidence that polyglutamylation can modulate protein phase separation.      <\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Authors:<\/h4>\n\n\n\n<p><strong>Marek Kravec<\/strong>, Ondrej \u0160edo, Jana Nedv\u011bdov\u00e1,<strong> Miroslav Micka, Marie \u0160ulcov\u00e1, Nikod\u00e9m Zezula, Krist\u00edna G\u00f6m\u00f6ryov\u00e1<\/strong>, David Pot\u011b\u0161il, Ranjani Sri Ganji, Sara Bologna, Igor \u010cervenka, Zbyn\u011bk Zdr\u00e1hal, <strong>Jakub Harno\u0161<\/strong>, Konstantinos Tripsiane, Carsten Janke, Cyril Ba\u0159inka, and <strong>V\u00edt\u011bzslav Bryja<\/strong><\/p>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns_03a500-1d{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns_03a500-1d .kt-button{font-weight:normal;font-style:normal;}.kt-btns_03a500-1d .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns_03a500-1d .kt-btn-wrap-0 .kt-button{color:#fff;background:#009900;border-color:#555555;}.wp-block-kadence-advancedbtn.kt-btns_03a500-1d .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_03a500-1d .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns_03a500-1d .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns_03a500-1d .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_03a500-1d .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kt-btn-align-center kt-btn-tablet-align-inherit kt-btn-mobile-align-inherit kt-btns-wrap kt-btns_03a500-1d\"><div class=\"kt-btn-wrap kt-btn-wrap-0\"><a class=\"kt-button kt-btn-0-action kt-btn-size-standard kt-btn-style-basic kt-btn-svg-show-always kt-btn-has-text-true kt-btn-has-svg-false\" href=\"https:\/\/www.embopress.org\/doi\/full\/10.1038\/s44318-024-00254-7\"><span class=\"kt-btn-inner-text\">Read the whole story<\/span><\/a><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Abstract Polyglutamylation is a reversible posttranslational modification that is catalyzed by enzymes of the tubulin tyrosine ligase-like (TTLL) family. Here, we found that TTLL11 generates a previously unknown type of polyglutamylation that is initiated by the addition of a glutamate &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/\">Read More<\/a><\/p>\n","protected":false},"author":10,"featured_media":12321,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[412,252],"tags":[],"class_list":["post-12320","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bryjalab","category-nova-publikace"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Carboxy-terminal polyglutamylation regulates signalling and phase separation of the Dishevelled protein - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Carboxy-terminal polyglutamylation regulates signalling and phase separation of the Dishevelled protein - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"Abstract Polyglutamylation is a reversible posttranslational modification that is catalyzed by enzymes of the tubulin tyrosine ligase-like (TTLL) family. Here, we found that TTLL11 generates a previously unknown type of polyglutamylation that is initiated by the addition of a glutamate &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Animal Physiology and Immunology\" \/>\n<meta property=\"article:published_time\" content=\"2024-10-01T10:31:20+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-29T10:37:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/10\/44318_2024_254_figa_html.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"550\" \/>\n\t<meta property=\"og:image:height\" content=\"398\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Kate\u0159ina Tomanov\u00e1\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Kate\u0159ina Tomanov\u00e1\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/\"},\"author\":{\"name\":\"Kate\u0159ina Tomanov\u00e1\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/c8812f5d8d8ff84f5f59ff6fc26ec134\"},\"headline\":\"Carboxy-terminal polyglutamylation regulates signalling and phase separation of the Dishevelled protein\",\"datePublished\":\"2024-10-01T10:31:20+00:00\",\"dateModified\":\"2024-10-29T10:37:27+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/\"},\"wordCount\":215,\"publisher\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/10\/44318_2024_254_figa_html.jpg\",\"articleSection\":[\"Bryjalab\",\"Nov\u00e1 publikace\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/\",\"name\":\"Carboxy-terminal polyglutamylation regulates signalling and phase separation of the Dishevelled protein - Department of Animal Physiology and Immunology\",\"isPartOf\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/10\/44318_2024_254_figa_html.jpg\",\"datePublished\":\"2024-10-01T10:31:20+00:00\",\"dateModified\":\"2024-10-29T10:37:27+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/#primaryimage\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/10\/44318_2024_254_figa_html.jpg\",\"contentUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/10\/44318_2024_254_figa_html.jpg\",\"width\":550,\"height\":398},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Carboxy-terminal polyglutamylation regulates signalling and phase separation of the Dishevelled protein\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#website\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/\",\"name\":\"Department of Animal Physiology and Immunology\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\",\"name\":\"Department of Animal Physiology and Immunology\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/logo_EN.png\",\"contentUrl\":\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/logo_EN.png\",\"width\":1903,\"height\":264,\"caption\":\"Department of Animal Physiology and Immunology\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/c8812f5d8d8ff84f5f59ff6fc26ec134\",\"name\":\"Kate\u0159ina Tomanov\u00e1\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/af79de1b34bfeaa8d21179d1901b634261fde8557e7e41b5866dfc65630b781e?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/af79de1b34bfeaa8d21179d1901b634261fde8557e7e41b5866dfc65630b781e?s=96&d=mm&r=g\",\"caption\":\"Kate\u0159ina Tomanov\u00e1\"},\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/author\/tomanova\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Carboxy-terminal polyglutamylation regulates signalling and phase separation of the Dishevelled protein - Department of Animal Physiology and Immunology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/","og_locale":"en_US","og_type":"article","og_title":"Carboxy-terminal polyglutamylation regulates signalling and phase separation of the Dishevelled protein - Department of Animal Physiology and Immunology","og_description":"Abstract Polyglutamylation is a reversible posttranslational modification that is catalyzed by enzymes of the tubulin tyrosine ligase-like (TTLL) family. Here, we found that TTLL11 generates a previously unknown type of polyglutamylation that is initiated by the addition of a glutamate &hellip; Read More","og_url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/","og_site_name":"Department of Animal Physiology and Immunology","article_published_time":"2024-10-01T10:31:20+00:00","article_modified_time":"2024-10-29T10:37:27+00:00","og_image":[{"width":550,"height":398,"url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/10\/44318_2024_254_figa_html.jpg","type":"image\/jpeg"}],"author":"Kate\u0159ina Tomanov\u00e1","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Kate\u0159ina Tomanov\u00e1","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/#article","isPartOf":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/"},"author":{"name":"Kate\u0159ina Tomanov\u00e1","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/c8812f5d8d8ff84f5f59ff6fc26ec134"},"headline":"Carboxy-terminal polyglutamylation regulates signalling and phase separation of the Dishevelled protein","datePublished":"2024-10-01T10:31:20+00:00","dateModified":"2024-10-29T10:37:27+00:00","mainEntityOfPage":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/"},"wordCount":215,"publisher":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization"},"image":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/#primaryimage"},"thumbnailUrl":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/10\/44318_2024_254_figa_html.jpg","articleSection":["Bryjalab","Nov\u00e1 publikace"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/","url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/","name":"Carboxy-terminal polyglutamylation regulates signalling and phase separation of the Dishevelled protein - Department of Animal Physiology and Immunology","isPartOf":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/#primaryimage"},"image":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/#primaryimage"},"thumbnailUrl":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/10\/44318_2024_254_figa_html.jpg","datePublished":"2024-10-01T10:31:20+00:00","dateModified":"2024-10-29T10:37:27+00:00","breadcrumb":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/#primaryimage","url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/10\/44318_2024_254_figa_html.jpg","contentUrl":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/10\/44318_2024_254_figa_html.jpg","width":550,"height":398},{"@type":"BreadcrumbList","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/carboxy-terminal-polyglutamylation-regulates-signalling-and-phase-separation-of-the-dishevelled-protein\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/ueb1.sci.muni.cz\/ofiz\/"},{"@type":"ListItem","position":2,"name":"Carboxy-terminal polyglutamylation regulates signalling and phase separation of the Dishevelled protein"}]},{"@type":"WebSite","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#website","url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/","name":"Department of Animal Physiology and Immunology","description":"","publisher":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ueb1.sci.muni.cz\/ofiz\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization","name":"Department of Animal Physiology and Immunology","url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/logo\/image\/","url":"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/logo_EN.png","contentUrl":"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/02\/logo_EN.png","width":1903,"height":264,"caption":"Department of Animal Physiology and Immunology"},"image":{"@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/c8812f5d8d8ff84f5f59ff6fc26ec134","name":"Kate\u0159ina Tomanov\u00e1","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/af79de1b34bfeaa8d21179d1901b634261fde8557e7e41b5866dfc65630b781e?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/af79de1b34bfeaa8d21179d1901b634261fde8557e7e41b5866dfc65630b781e?s=96&d=mm&r=g","caption":"Kate\u0159ina Tomanov\u00e1"},"url":"https:\/\/ueb1.sci.muni.cz\/ofiz\/author\/tomanova\/"}]}},"_links":{"self":[{"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/posts\/12320","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/comments?post=12320"}],"version-history":[{"count":1,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/posts\/12320\/revisions"}],"predecessor-version":[{"id":12322,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/posts\/12320\/revisions\/12322"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/media\/12321"}],"wp:attachment":[{"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/media?parent=12320"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/categories?post=12320"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-json\/wp\/v2\/tags?post=12320"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}