{"id":11592,"date":"2023-08-20T14:12:16","date_gmt":"2023-08-20T14:12:16","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=11592"},"modified":"2024-04-08T14:15:37","modified_gmt":"2024-04-08T14:15:37","slug":"spatiotemporal-monitoring-of-hard-tissue-development-reveals-unknown-features-of-tooth-and-bone-development","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/spatiotemporal-monitoring-of-hard-tissue-development-reveals-unknown-features-of-tooth-and-bone-development\/","title":{"rendered":"Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development"},"content":{"rendered":"\n<p><strong>Abstract:<\/strong><\/p>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p>Mineralized tissues, such as bones or teeth, are essential structures of all vertebrates. They enable rapid movement, protection, and food processing, in addition to providing physiological functions. Although the development, regeneration, and pathogenesis of teeth and bones have been intensely studied, there is currently no tool to accurately follow the dynamics of growth and healing of these vital tissues in space and time. Here, we present the BEE-ST (Bones and tEEth Spatio-Temporal growth monitoring) approach, which allows precise quantification of development, regeneration, remodeling, and healing in any type of calcified tissue across different species. Using mouse teeth as model the turnover rate of continuously growing incisors was quantified, and role of hard\/soft diet on molar root growth was shown. Furthermore, the dynamics of bones and teeth growth in lizards, frogs, birds, and zebrafish was uncovered. This approach represents an effective, highly reproducible, and versatile tool that opens up diverse possibilities in developmental biology, bone and tooth healing, tissue engineering, and disease modeling.<\/p>\n<\/div>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns_5c852e-a6{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns_5c852e-a6 .kt-button{font-weight:normal;font-style:normal;}.kt-btns_5c852e-a6 .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns_5c852e-a6 .kt-btn-wrap-0 .kt-button{color:#fff;background:#009900;border-color:#fff;box-shadow:1px 1px 5px 0px rgba(0, 0, 0, 0.2);}.wp-block-kadence-advancedbtn.kt-btns_5c852e-a6 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_5c852e-a6 .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns_5c852e-a6 .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns_5c852e-a6 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_5c852e-a6 .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kt-btn-align-center kt-btn-tablet-align-inherit kt-btn-mobile-align-inherit kt-btns-wrap kt-btns_5c852e-a6\"><div class=\"kt-btn-wrap kt-btn-wrap-0\"><a class=\"kt-button kt-btn-0-action kt-btn-size-standard kt-btn-style-basic kt-btn-svg-show-always kt-btn-has-text-true kt-btn-has-svg-false\" href=\"https:\/\/www.science.org\/doi\/full\/10.1126\/sciadv.adi0482\"><span class=\"kt-btn-inner-text\">Read the whole story<\/span><\/a><\/div><\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img loading=\"lazy\" decoding=\"async\" width=\"750\" height=\"922\" src=\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/04\/sciadv.adi0482-f1.jpg\" alt=\"\" class=\"wp-image-11593\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/04\/sciadv.adi0482-f1.jpg 750w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/04\/sciadv.adi0482-f1-244x300.jpg 244w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/04\/sciadv.adi0482-f1-740x910.jpg 740w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/04\/sciadv.adi0482-f1-370x455.jpg 370w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/04\/sciadv.adi0482-f1-560x688.jpg 560w\" sizes=\"auto, (max-width: 750px) 100vw, 750px\" \/><\/figure><\/div>\n\n\n\n<p><strong data-rich-text-format-boundary=\"true\"> Fig.\u00a01.. Possibilities of the BEE-ST growth monitoring technique application. <\/strong><em>We present the BEE-ST approach for tracking the dynamics of hard tissue growth in space and time. Our approach is applicable to all main groups of vertebrates represented by their model organisms: mammals (M. musculus), reptiles (C. calyptratus), birds (G. gallus), amphibians (X. laevis), and fish (D. rerio). It is based on the sequential administration of calcium-incorporating fluorescent dyes, followed by optical tissue clearing of fully calcified hard tissues, whole-mount imaging, and subsequent precise quantification of the growth in a micrometer scale. BEE-ST has many potential applications in fundamental biology, tissue engineering, or disease modeling. Scale bars, 100 \u03bcm. 3D, three-dimensional.<\/em><\/p>\n<p>\u00a0<\/p>\n\n\n\n<p><strong>Authors:<\/strong><\/p>\n<p>Marcos Gonzalez Lopez\u00a0 <sup>1<\/sup> , Barbora Huteckova\u00a0 <sup>2, 3<\/sup> , Josef Lavicky\u00a0 <sup>1<\/sup> , <strong>Nikodem Zezula\u00a0 <sup>2<\/sup><\/strong> , Vladislav Rakultsev\u00a0 <sup>1<\/sup> , Vendula Fridrichova\u00a0 <sup>1<\/sup> , Haneen Tuaima\u00a0 <sup>1<\/sup> , Cita Nottmeier\u00a0 <sup>4<\/sup> , Julian Petersen\u00a0<sup> 4<\/sup> , Michaela Kavkova\u00a0 <sup>1, 5<\/sup> , Tomas Zikmund\u00a0 <sup>5<\/sup> , Jozef Kaiser\u00a0 <sup>5<\/sup> , Rupali Lav\u00a0 <sup>6<\/sup> , Haza Star\u00a0 <sup>6<\/sup> , <strong>V\u00edt\u011bzslav Bryja\u00a0 <sup>2<\/sup><\/strong> , Petr Heny\u0161\u00a0 <sup>7<\/sup> , Miroslav Vo\u0159echovsk\u00fd\u00a0<sup> 8<\/sup> , Abigail S Tucker\u00a0<sup> 6, 9<\/sup> , Jakub Harnos\u00a0 <sup>2<\/sup> , Marcela Buchtova\u00a0 <sup>2, 3<\/sup> , Jan Krivanek\u00a0 <sup>1<\/sup><\/p>\n\n\n\n<ul class=\"item-list\">\n<li id=\"full-view-affiliation-1\" data-affiliation-id=\"full-view-affiliation-1\"><sup class=\"key\">1<\/sup> Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.<\/li>\n<li id=\"full-view-affiliation-2\" data-affiliation-id=\"full-view-affiliation-2\"><strong><sup class=\"key\">2<\/sup> Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic<\/strong>.<\/li>\n<li id=\"full-view-affiliation-3\" data-affiliation-id=\"full-view-affiliation-3\"><sup class=\"key\">3<\/sup> Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czech Republic.<\/li>\n<li id=\"full-view-affiliation-4\" data-affiliation-id=\"full-view-affiliation-4\"><sup class=\"key\">4<\/sup> Department of Orthodontics, University of Leipzig Medical Center, Leipzig, Germany.<\/li>\n<li id=\"full-view-affiliation-5\" data-affiliation-id=\"full-view-affiliation-5\"><sup class=\"key\">5<\/sup> Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.<\/li>\n<li id=\"full-view-affiliation-6\" data-affiliation-id=\"full-view-affiliation-6\"><sup class=\"key\">6<\/sup> Centre for Craniofacial and Regenerative Biology, King&#8217;s College London, London, UK.<\/li>\n<li id=\"full-view-affiliation-7\" data-affiliation-id=\"full-view-affiliation-7\"><sup class=\"key\">7<\/sup> Institute of New Technologies and Applied Informatics, Faculty of Mechatronics, Informatics and Interdisciplinary Studies, Technical University of Liberec, Liberec, Czech Republic.<\/li>\n<li id=\"full-view-affiliation-8\" data-affiliation-id=\"full-view-affiliation-8\"><sup class=\"key\">8<\/sup> Institute of Structural Mechanics, Faculty of Civil Engineering, Brno University of Technology, Czech Republic.<\/li>\n<li id=\"full-view-affiliation-9\" data-affiliation-id=\"full-view-affiliation-9\"><sup class=\"key\">9<\/sup> Institute of Histology and Embryology, First Faculty of Medicine, Charles University, Prague, Czech Republic.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Abstract: Mineralized tissues, such as bones or teeth, are essential structures of all vertebrates. They enable rapid movement, protection, and food processing, in addition to providing physiological functions. Although the development, regeneration, and pathogenesis of teeth and bones have been &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/spatiotemporal-monitoring-of-hard-tissue-development-reveals-unknown-features-of-tooth-and-bone-development\/\">Read More<\/a><\/p>\n","protected":false},"author":5,"featured_media":11593,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[412,252],"tags":[304],"class_list":["post-11592","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bryjalab","category-nova-publikace","tag-bryjalab"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/spatiotemporal-monitoring-of-hard-tissue-development-reveals-unknown-features-of-tooth-and-bone-development\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"Abstract: Mineralized tissues, such as bones or teeth, are essential structures of all vertebrates. They enable rapid movement, protection, and food processing, in addition to providing physiological functions. Although the development, regeneration, and pathogenesis of teeth and bones have been &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/spatiotemporal-monitoring-of-hard-tissue-development-reveals-unknown-features-of-tooth-and-bone-development\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Animal Physiology and Immunology\" \/>\n<meta property=\"article:published_time\" content=\"2023-08-20T14:12:16+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-04-08T14:15:37+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/04\/sciadv.adi0482-f1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"750\" \/>\n\t<meta property=\"og:image:height\" content=\"922\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Lucie Nesvadbov\u00e1\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lucie Nesvadbov\u00e1\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/spatiotemporal-monitoring-of-hard-tissue-development-reveals-unknown-features-of-tooth-and-bone-development\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/spatiotemporal-monitoring-of-hard-tissue-development-reveals-unknown-features-of-tooth-and-bone-development\/\"},\"author\":{\"name\":\"Lucie Nesvadbov\u00e1\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/3119766c8e4c78f08bbbde220469aee6\"},\"headline\":\"Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development\",\"datePublished\":\"2023-08-20T14:12:16+00:00\",\"dateModified\":\"2024-04-08T14:15:37+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/spatiotemporal-monitoring-of-hard-tissue-development-reveals-unknown-features-of-tooth-and-bone-development\/\"},\"wordCount\":459,\"publisher\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/spatiotemporal-monitoring-of-hard-tissue-development-reveals-unknown-features-of-tooth-and-bone-development\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/04\/sciadv.adi0482-f1.jpg\",\"keywords\":[\"Bryjalab\"],\"articleSection\":[\"Bryjalab\",\"Nov\u00e1 publikace\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/spatiotemporal-monitoring-of-hard-tissue-development-reveals-unknown-features-of-tooth-and-bone-development\/\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/spatiotemporal-monitoring-of-hard-tissue-development-reveals-unknown-features-of-tooth-and-bone-development\/\",\"name\":\"Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development - 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