{"id":11333,"date":"2024-01-22T10:09:39","date_gmt":"2024-01-22T10:09:39","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=11333"},"modified":"2024-01-22T10:13:35","modified_gmt":"2024-01-22T10:13:35","slug":"multifunctional-graphene-quantum-dots-a-therapeutic-strategy-for-neurodegenerative-diseases-by-regulating-calcium-influx-crossing-the-blood-brain-barrier-and-inhibiting-a%ce%b2-protein-aggregatio","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/multifunctional-graphene-quantum-dots-a-therapeutic-strategy-for-neurodegenerative-diseases-by-regulating-calcium-influx-crossing-the-blood-brain-barrier-and-inhibiting-a%ce%b2-protein-aggregatio\/","title":{"rendered":"Multifunctional graphene quantum dots: A therapeutic strategy for neurodegenerative diseases by regulating calcium influx, crossing the blood-brain barrier and inhibiting A\u03b2-protein aggregation"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p>Multifunctional  nanoparticles could be the hallmark for the treatment of  neurodegenerative diseases. Dissociation of protein aggregates causing  neuronal damage and transfer of specific drugs which can downregulate  neuronal excitotoxicity by inhibiting glutamatergic N-Methyl-d-Aspartate-receptors  (NMDA) and then reducing calcium influx are among the main factors to  consider for proper therapy. Here, we present a multiplatform based on  nitrogen-doped graphene quantum dots (NGQDs) with such functionalities.  The NGQDs were functionalized with Memantine, the clinically used drug,  via covalent and non-covalent coupling, and we confirmed that the  pharmaceutical activity was not altered. Apart from that, using  xCELLigence technology and flow cytometric analysis of ABC transporter  function, we uncovered that the ABC transporters of the blood-brain  barrier (BBB) do not affect the ability of NGQD to cross BBB.  Surprisingly, this study found that NGQDs have an inhibitory effect on  NMDA receptors, thus supporting the action of Memantine. Moreover, NGQDs  and their derivatives demonstrated the potential to dissociate  \u03b2-amyloid aggregates while possessing features suitable for bioimaging  in various cell lines.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"397\" src=\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/01\/1-s2.0-S2352940724000180-ga1_lrg-1024x397.jpg\" alt=\"\" class=\"wp-image-11334\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/01\/1-s2.0-S2352940724000180-ga1_lrg-1024x397.jpg 1024w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/01\/1-s2.0-S2352940724000180-ga1_lrg-300x116.jpg 300w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/01\/1-s2.0-S2352940724000180-ga1_lrg-768x298.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns_7e77bb-91{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns_7e77bb-91 .kt-button{font-weight:normal;font-style:normal;}.kt-btns_7e77bb-91 .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns_7e77bb-91 .kt-btn-wrap-0 .kt-button{color:#fff;background:#009900;border-color:#eee;box-shadow:1px 1px 2px 0px rgba(0, 0, 0, 0.2);}.wp-block-kadence-advancedbtn.kt-btns_7e77bb-91 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_7e77bb-91 .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns_7e77bb-91 .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns_7e77bb-91 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_7e77bb-91 .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kt-btn-align-center kt-btn-tablet-align-inherit kt-btn-mobile-align-inherit kt-btns-wrap kt-btns_7e77bb-91\"><div class=\"kt-btn-wrap kt-btn-wrap-0\"><a class=\"kt-button kt-btn-0-action kt-btn-size-standard kt-btn-style-basic kt-btn-svg-show-always kt-btn-has-text-true kt-btn-has-svg-false\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2352940724000180\"><span class=\"kt-btn-inner-text\">Read the whole story<\/span><\/a><\/div><\/div>\n\n\n\n<p><strong>Authors: <\/strong><\/p>\n\n\n\n<p>I. Jennifer Gomez* (a,b), <strong>Petra K\u0159\u00ed\u017ekov\u00e1 (c,d)<\/strong>, <strong>Anna Dole\u010dkov\u00e1 (c,d)<\/strong>, Luc\u00eda Cardo (d), Cecilia Wetzl (d,e), Nad\u011b\u017eda Piz\u00farov\u00e1 (f), Maurizio Prato (d,g,h), <strong>Ji\u0159ina Medalov\u00e1* (c)<\/strong>, Lenka Zaj\u00ed\u010dkov\u00e1* a,i<\/p>\n\n\n\n<p>*corresponding authors<\/p>\n\n\n\n<p><strong>Affiliation: <\/strong><\/p>\n\n\n\n<p><sup>a<\/sup>Department of Condensed Matter Physics, Faculty of Science, Masaryk University, 61137 Brno, Czech Republic<\/p>\n\n\n\n<p><sup>b<\/sup>Centro Interdisciplinar de Qu\u00edmica e Biolox\u00eda (CICA), Universidade da Coru\u00f1a, R\u00faa As Carballeiras, 15071 A Coru\u00f1a, Spain<\/p>\n\n\n\n<p><sup>c<\/sup>Department of Experimental Biology, Faculty of Science, Masaryk University, 62500 Brno, Czech Republic<\/p>\n\n\n\n<p><sup>d<\/sup>Center  for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque  Research and Technology Alliance (BRTA), 20014 Donostia-San Sebasti\u00e1n,  Spain<\/p>\n\n\n\n<p><sup>e<\/sup>University of the Basque Country, UPV-EHU, 20018 San Sebasti\u00e1n, Spain<\/p>\n\n\n\n<p><sup>f<\/sup>Institute of Physics of Materials, Czech Academy of Sciences, 61662 Brno, Czech Republic<\/p>\n\n\n\n<p><sup>g<\/sup>Department of Chemical and Pharmaceutical Sciences, University of Trieste, 34127 Trieste, Italy<\/p>\n\n\n\n<p><sup>h<\/sup>Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain<\/p>\n\n\n\n<p><sup>i<\/sup>Central European Institute of Technology &#8211; CEITEC, Brno University of Technology, 61200 Brno, Czech Republic <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract Multifunctional nanoparticles could be the hallmark for the treatment of neurodegenerative diseases. Dissociation of protein aggregates causing neuronal damage and transfer of specific drugs which can downregulate neuronal excitotoxicity by inhibiting glutamatergic N-Methyl-d-Aspartate-receptors (NMDA) and then reducing calcium influx &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/multifunctional-graphene-quantum-dots-a-therapeutic-strategy-for-neurodegenerative-diseases-by-regulating-calcium-influx-crossing-the-blood-brain-barrier-and-inhibiting-a%ce%b2-protein-aggregatio\/\">Read More<\/a><\/p>\n","protected":false},"author":10,"featured_media":11335,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[252],"tags":[],"class_list":["post-11333","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nova-publikace"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Multifunctional graphene quantum dots: A therapeutic strategy for neurodegenerative diseases by regulating calcium influx, crossing the blood-brain barrier and inhibiting A\u03b2-protein aggregation - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/multifunctional-graphene-quantum-dots-a-therapeutic-strategy-for-neurodegenerative-diseases-by-regulating-calcium-influx-crossing-the-blood-brain-barrier-and-inhibiting-a\u03b2-protein-aggregatio\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Multifunctional graphene quantum dots: A therapeutic strategy for neurodegenerative diseases by regulating calcium influx, crossing the blood-brain barrier and inhibiting A\u03b2-protein aggregation - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"Abstract Multifunctional nanoparticles could be the hallmark for the treatment of neurodegenerative diseases. Dissociation of protein aggregates causing neuronal damage and transfer of specific drugs which can downregulate neuronal excitotoxicity by inhibiting glutamatergic N-Methyl-d-Aspartate-receptors (NMDA) and then reducing calcium influx &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/multifunctional-graphene-quantum-dots-a-therapeutic-strategy-for-neurodegenerative-diseases-by-regulating-calcium-influx-crossing-the-blood-brain-barrier-and-inhibiting-a\u03b2-protein-aggregatio\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Animal Physiology and Immunology\" \/>\n<meta property=\"article:published_time\" content=\"2024-01-22T10:09:39+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-22T10:13:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/01\/1-s2.0-S2352940724000180-ga1_lrg-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2213\" \/>\n\t<meta property=\"og:image:height\" content=\"858\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Kate\u0159ina Tomanov\u00e1\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Kate\u0159ina Tomanov\u00e1\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/multifunctional-graphene-quantum-dots-a-therapeutic-strategy-for-neurodegenerative-diseases-by-regulating-calcium-influx-crossing-the-blood-brain-barrier-and-inhibiting-a%ce%b2-protein-aggregatio\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/multifunctional-graphene-quantum-dots-a-therapeutic-strategy-for-neurodegenerative-diseases-by-regulating-calcium-influx-crossing-the-blood-brain-barrier-and-inhibiting-a%ce%b2-protein-aggregatio\/\"},\"author\":{\"name\":\"Kate\u0159ina Tomanov\u00e1\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/c8812f5d8d8ff84f5f59ff6fc26ec134\"},\"headline\":\"Multifunctional graphene quantum dots: A therapeutic strategy for neurodegenerative diseases by regulating calcium influx, crossing the blood-brain barrier and inhibiting A\u03b2-protein aggregation\",\"datePublished\":\"2024-01-22T10:09:39+00:00\",\"dateModified\":\"2024-01-22T10:13:35+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/multifunctional-graphene-quantum-dots-a-therapeutic-strategy-for-neurodegenerative-diseases-by-regulating-calcium-influx-crossing-the-blood-brain-barrier-and-inhibiting-a%ce%b2-protein-aggregatio\/\"},\"wordCount\":357,\"publisher\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/multifunctional-graphene-quantum-dots-a-therapeutic-strategy-for-neurodegenerative-diseases-by-regulating-calcium-influx-crossing-the-blood-brain-barrier-and-inhibiting-a%ce%b2-protein-aggregatio\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2024\/01\/1-s2.0-S2352940724000180-ga1_lrg-1.jpg\",\"articleSection\":[\"Nov\u00e1 publikace\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/multifunctional-graphene-quantum-dots-a-therapeutic-strategy-for-neurodegenerative-diseases-by-regulating-calcium-influx-crossing-the-blood-brain-barrier-and-inhibiting-a%ce%b2-protein-aggregatio\/\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/multifunctional-graphene-quantum-dots-a-therapeutic-strategy-for-neurodegenerative-diseases-by-regulating-calcium-influx-crossing-the-blood-brain-barrier-and-inhibiting-a%ce%b2-protein-aggregatio\/\",\"name\":\"Multifunctional graphene quantum dots: A therapeutic strategy for neurodegenerative diseases by regulating calcium influx, crossing the blood-brain barrier and inhibiting A\u03b2-protein aggregation - 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