{"id":10644,"date":"2023-06-12T14:00:34","date_gmt":"2023-06-12T14:00:34","guid":{"rendered":"http:\/\/www.sci.muni.cz\/ofiz\/?p=10644"},"modified":"2023-06-12T14:01:32","modified_gmt":"2023-06-12T14:01:32","slug":"a-previously-uncharacterized-factor-associated-with-metabolism-and-energy-fame-c14orf105-ccdc198-1700011h14rik-is-related-to-evolutionary-adaptation-energy-balance-and-kidney-physiology-2","status":"publish","type":"post","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-previously-uncharacterized-factor-associated-with-metabolism-and-energy-fame-c14orf105-ccdc198-1700011h14rik-is-related-to-evolutionary-adaptation-energy-balance-and-kidney-physiology-2\/","title":{"rendered":"A previously uncharacterized Factor Associated with Metabolism and Energy (FAME\/C14orf105\/CCDC198\/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology"},"content":{"rendered":"\n<p><strong>Abstract:<\/strong><\/p>\n<p>In this study we use comparative genomics to uncover a gene with uncharacterized function (1700011H14Rik\/C14orf105\/CCDC198), which we hereby name FAME (Factor Associated with Metabolism and Energy). We observe that FAME shows an unusually high evolutionary divergence in birds and mammals. Through the comparison of single nucleotide polymorphisms, we identify gene flow of FAME from Neandertals into modern humans. We conduct knockout experiments on animals and observe altered body weight and decreased energy expenditure in Fame knockout animals, corresponding to genome-wide association studies linking FAME with higher body mass index in humans. Gene expression and subcellular localization analyses reveal that FAME is a membrane-bound protein enriched in the kidneys. Although the gene knockout results in structurally normal kidneys, we detect higher albumin in urine and lowered ferritin in the blood. Through experimental validation, we confirm interactions between FAME and ferritin and show co-localization in vesicular and plasma membranes.<\/p>\n\n\n<style>#kt-layout-id_aa4450-c2 > .kt-row-column-wrap{align-content:start;}:where(#kt-layout-id_aa4450-c2 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}#kt-layout-id_aa4450-c2 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var( --global-kb-row-default-top, 25px );padding-bottom:var( --global-kb-row-default-bottom, 25px );padding-bottom:0px;}#kt-layout-id_aa4450-c2 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}#kt-layout-id_aa4450-c2 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr) minmax(0, 6fr) minmax(0, 1fr);}#kt-layout-id_aa4450-c2 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){#kt-layout-id_aa4450-c2 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 1024px){#kt-layout-id_aa4450-c2 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr) minmax(0, 6fr) minmax(0, 1fr);}}@media all and (max-width: 767px){#kt-layout-id_aa4450-c2 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}#kt-layout-id_aa4450-c2 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style>\n<div class=\"wp-block-kadence-rowlayout alignnone\"><div id=\"kt-layout-id_aa4450-c2\" class=\"kt-row-layout-inner  kt-layout-id_aa4450-c2\"><div class=\"kt-row-column-wrap kt-has-3-columns kt-gutter-default kt-v-gutter-default kt-row-valign-top kt-row-layout-center-exwide kt-tab-layout-inherit kt-m-colapse-left-to-right kt-mobile-layout-row\"><style>.kadence-column_983f3c-b6 > .kt-inside-inner-col{border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;}.kadence-column_983f3c-b6 > .kt-inside-inner-col,.kadence-column_983f3c-b6 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column_983f3c-b6 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column_983f3c-b6 > .kt-inside-inner-col{flex-direction:column;}.kadence-column_983f3c-b6 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column_983f3c-b6 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column_983f3c-b6{position:relative;}@media all and (max-width: 1024px){.kadence-column_983f3c-b6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column_983f3c-b6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column inner-column-1 kadence-column_983f3c-b6\"><div class=\"kt-inside-inner-col\">\n<p><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column_a9698b-38 > .kt-inside-inner-col{border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;}.kadence-column_a9698b-38 > .kt-inside-inner-col,.kadence-column_a9698b-38 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column_a9698b-38 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column_a9698b-38 > .kt-inside-inner-col{flex-direction:column;}.kadence-column_a9698b-38 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column_a9698b-38 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column_a9698b-38{position:relative;}@media all and (max-width: 1024px){.kadence-column_a9698b-38 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column_a9698b-38 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column inner-column-2 kadence-column_a9698b-38\"><div class=\"kt-inside-inner-col\">\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img loading=\"lazy\" decoding=\"async\" width=\"564\" height=\"612\" src=\"https:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2023\/06\/publication_peterson.jpg\" alt=\"\" class=\"wp-image-10637\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2023\/06\/publication_peterson.jpg 564w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2023\/06\/publication_peterson-276x300.jpg 276w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2023\/06\/publication_peterson-370x401.jpg 370w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2023\/06\/publication_peterson-560x608.jpg 560w\" sizes=\"auto, (max-width: 564px) 100vw, 564px\" \/><figcaption> <\/figcaption><\/figure><\/div>\n<\/div><\/div>\n\n\n<style>.kadence-column_9aae43-8d > .kt-inside-inner-col{border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;}.kadence-column_9aae43-8d > .kt-inside-inner-col,.kadence-column_9aae43-8d > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column_9aae43-8d > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column_9aae43-8d > .kt-inside-inner-col{flex-direction:column;}.kadence-column_9aae43-8d > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column_9aae43-8d > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column_9aae43-8d{position:relative;}@media all and (max-width: 1024px){.kadence-column_9aae43-8d > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column_9aae43-8d > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column inner-column-3 kadence-column_9aae43-8d\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n\n<p style=\"text-align: center;\"><span style=\"color: #808080;\"><em>Single nucleotide polymorphisms (SNPs) for which Neanderthals (n\u2009=\u20093) and Yorubans (n\u2009=\u2009108) homozygously carry different alleles. Genomic coordinates are in hg19. The ancestral alleles were taken from Ensembl<sup><a style=\"color: #808080;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10226981\/#CR90\">90<\/a><\/sup> and the Neanderthal alleles from previously published genomes<sup><a style=\"color: #808080;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10226981\/#CR27\">27<\/a>,<a style=\"color: #808080;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10226981\/#CR28\">28<\/a><\/sup>.<\/em> <\/span><\/p>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns_a2c56e-f3{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns_a2c56e-f3 .kt-button{font-weight:normal;font-style:normal;}.kt-btns_a2c56e-f3 .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns_a2c56e-f3 .kt-btn-wrap-0 .kt-button{color:#fff;background:#009900;border-color:#fff;box-shadow:1px 1px 2px 3px rgba(0, 0, 0, 0.2);}.wp-block-kadence-advancedbtn.kt-btns_a2c56e-f3 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_a2c56e-f3 .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns_a2c56e-f3 .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns_a2c56e-f3 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns_a2c56e-f3 .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kt-btn-align-center kt-btn-tablet-align-inherit kt-btn-mobile-align-inherit kt-btns-wrap kt-btns_a2c56e-f3\"><div class=\"kt-btn-wrap kt-btn-wrap-0\"><a class=\"kt-button kt-btn-0-action kt-btn-size-standard kt-btn-style-basic kt-btn-svg-show-always kt-btn-has-text-true kt-btn-has-svg-false\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10226981\/\"><span class=\"kt-btn-inner-text\">Read the whole story<\/span><\/a><\/div><\/div>\n\n\n\n<p><strong>Authors:<\/strong><\/p>\n<p>Julian Petersen <sup>1<\/sup>, Lukas Englmaier <sup>2,3<\/sup>, Artem Artemov <sup>4<\/sup>, Irina Poverennaya <sup>4<\/sup>, Ruba Mahmoud <sup>5<\/sup>, Thibault Bouderlique <sup>4<\/sup>, Marketa Tesarova <sup>6<\/sup>, Ruslan Deviatiiarov <sup>7,8<\/sup>, Anett Szilv\u00e1sy-Szab\u00f3 <sup>9<\/sup>, Evgeny Akkuratov <sup>10,11<\/sup>, David Pajuelo Reguera <sup>12<\/sup>, Hugo Zeberg <sup>13,14<\/sup>, Marketa Kaucka <sup>15<\/sup>, Maria Eleni Kastriti <sup>4,14<\/sup>, Jan Krivanek <sup>16<\/sup>, <strong>Tomasz Radaszkiewicz <sup>17<\/sup>, Krist\u00edna G\u00f6m\u00f6ryov\u00e1 <sup>17<\/sup><\/strong>, Sarah Knauth <sup>&nbsp;5<\/sup> , David Potesil <sup>18<\/sup>, Zbynek Zdrahal <sup>18<\/sup>, Ranjani Sri Ganji <sup>18<\/sup>, Anna Grabowski <sup>4<\/sup>, Miriam Buhl <sup>19<\/sup>, Tomas Zikmund <sup>6<\/sup>, Michaela Kavkova <sup>6,16 <\/sup>, H\u00e5kan Axelson <sup>20<\/sup>, David Lindgren <sup>20<\/sup>, Rafael Kramann <sup>21<\/sup>, Christoph Kuppe <sup>21<\/sup>, Ferenc Erd\u00e9lyi <sup>22<\/sup>, Zolt\u00e1n M\u00e1t\u00e9 <sup>22<\/sup>, G\u00e1bor Szab\u00f3 <sup>22<\/sup>, Till Koehne <sup>5<\/sup>, Tibor Harkany <sup>23<\/sup>, Kaj Fried <sup>14<\/sup>, Jozef Kaiser <sup>6<\/sup>, Peter Boor <sup>19<\/sup>, Csaba Fekete <sup>9<\/sup>, Jan Rozman <sup>12,24<\/sup>, Petr Kasparek <sup>12<\/sup>, Jan Prochazka <sup>12<\/sup>, Radislav Sedlacek <sup>12<\/sup>, <strong>Vitezslav Bryja <sup>17<\/sup><\/strong>, Oleg Gusev <sup>8,25,26<\/sup>, Igor Adameyko <sup>27,28<\/sup><\/p>\n\n\n\n<p>&nbsp;<\/p>\n<p><strong>Affiliations <\/strong><\/p>\n<ul>\n<li><sup>1<\/sup> Department of Orthodontics, University Leipzig Medical Center, Leipzig, Germany. julian.petersen@medizin.uni-leipzig.de.<\/li>\n<li><sup>2<\/sup> CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090, Vienna, Austria.<\/li>\n<li><sup>3<\/sup> Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, 1090, Vienna, Austria.<\/li>\n<li><sup>4<\/sup> Department of Neuroimmunology, Center for Brain Research, Medical University Vienna, Vienna, Austria.<\/li>\n<li><sup>5<\/sup> Department of Orthodontics, University Leipzig Medical Center, Leipzig, Germany.<\/li>\n<li><sup>6<\/sup> Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.<\/li>\n<li><sup>7<\/sup> Regulatory Genomics Research Center, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.<\/li>\n<li><sup>8<\/sup> Endocrinology Research Center, Moscow, Russia.<\/li>\n<li><sup>9<\/sup> Laboratory of Integrative Neuroendocrinology, Institute of Experimental Medicine, 1083, Budapest, Hungary.<\/li>\n<li><sup>10<\/sup> Department of Applied Physics, Royal Institute of Technology, Science for Life Laboratory, 171 65, Stockholm, Sweden.<\/li>\n<li><sup>11<\/sup> University of Oxford, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford, OX3 9DS, UK.<\/li>\n<li><sup>12<\/sup> Institute of Molecular Genetics of the Czech Academy of Science, Czech Centre for Phenogenomics, Vestec, Czech Republic.<\/li>\n<li><sup>13<\/sup> Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.<\/li>\n<li><sup>14<\/sup> Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.<\/li>\n<li><sup>15<\/sup> Max Planck Institute for Evolutionary Biology, Pl\u00f6n, 24306, Germany.<\/li>\n<li><sup>16<\/sup> Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.<\/li>\n<li><strong><sup>17<\/sup> Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.<\/strong><\/li>\n<li><sup>18<\/sup> Central European Institute of Technology, Masaryk University, Brno, Czech Republic.<\/li>\n<li><sup>19<\/sup> Institute of Pathology &amp; Electron Microscopy Facility, RWTH Aachen University Hospital, Aachen, Germany.<\/li>\n<li><sup>20<\/sup> Translational Cancer Research, Department of Laboratory Medicine, Lund University, Medicon Village, Scheelev\u00e4gen 2, Lund, Sweden.<\/li>\n<li><sup>21<\/sup> Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.<\/li>\n<li><sup>22<\/sup> Medical Gene Technology Unit, Institute of Experimental Medicine, Budapest, Hungary.<\/li>\n<li><sup>23<\/sup> Department of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, Vienna, Austria.<\/li>\n<li><sup>24<\/sup> Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 6, avenue du Swing, 4367, Belvaux, Luxembourg.<\/li>\n<li><sup>25<\/sup> Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.<\/li>\n<li><sup>26<\/sup> Center for Integrative Medical Sciences, RIKEN, Yokohama City, Kanagawa, Japan.<\/li>\n<li><sup>27<\/sup> Department of Neuroimmunology, Center for Brain Research, Medical University Vienna, Vienna, Austria. igor.adameyko@meduniwien.ac.at.<\/li>\n<li><sup>28<\/sup> Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. igor.adameyko@meduniwien.ac.at.<\/li>\n<\/ul>\n<p><sup>#<\/sup> Contributed equally.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract: In this study we use comparative genomics to uncover a gene with uncharacterized function (1700011H14Rik\/C14orf105\/CCDC198), which we hereby name FAME (Factor Associated with Metabolism and Energy). We observe that FAME shows an unusually high evolutionary divergence in birds and &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-previously-uncharacterized-factor-associated-with-metabolism-and-energy-fame-c14orf105-ccdc198-1700011h14rik-is-related-to-evolutionary-adaptation-energy-balance-and-kidney-physiology-2\/\">Read More<\/a><\/p>\n","protected":false},"author":5,"featured_media":10637,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[256],"tags":[],"class_list":["post-10644","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-new-paper"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A previously uncharacterized Factor Associated with Metabolism and Energy (FAME\/C14orf105\/CCDC198\/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-previously-uncharacterized-factor-associated-with-metabolism-and-energy-fame-c14orf105-ccdc198-1700011h14rik-is-related-to-evolutionary-adaptation-energy-balance-and-kidney-physiology-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A previously uncharacterized Factor Associated with Metabolism and Energy (FAME\/C14orf105\/CCDC198\/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"Abstract: In this study we use comparative genomics to uncover a gene with uncharacterized function (1700011H14Rik\/C14orf105\/CCDC198), which we hereby name FAME (Factor Associated with Metabolism and Energy). We observe that FAME shows an unusually high evolutionary divergence in birds and &hellip; Read More\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-previously-uncharacterized-factor-associated-with-metabolism-and-energy-fame-c14orf105-ccdc198-1700011h14rik-is-related-to-evolutionary-adaptation-energy-balance-and-kidney-physiology-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Animal Physiology and Immunology\" \/>\n<meta property=\"article:published_time\" content=\"2023-06-12T14:00:34+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-12T14:01:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2023\/06\/publication_peterson.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"564\" \/>\n\t<meta property=\"og:image:height\" content=\"612\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Lucie Nesvadbov\u00e1\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lucie Nesvadbov\u00e1\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-previously-uncharacterized-factor-associated-with-metabolism-and-energy-fame-c14orf105-ccdc198-1700011h14rik-is-related-to-evolutionary-adaptation-energy-balance-and-kidney-physiology-2\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-previously-uncharacterized-factor-associated-with-metabolism-and-energy-fame-c14orf105-ccdc198-1700011h14rik-is-related-to-evolutionary-adaptation-energy-balance-and-kidney-physiology-2\/\"},\"author\":{\"name\":\"Lucie Nesvadbov\u00e1\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#\/schema\/person\/3119766c8e4c78f08bbbde220469aee6\"},\"headline\":\"A previously uncharacterized Factor Associated with Metabolism and Energy (FAME\/C14orf105\/CCDC198\/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology\",\"datePublished\":\"2023-06-12T14:00:34+00:00\",\"dateModified\":\"2023-06-12T14:01:32+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-previously-uncharacterized-factor-associated-with-metabolism-and-energy-fame-c14orf105-ccdc198-1700011h14rik-is-related-to-evolutionary-adaptation-energy-balance-and-kidney-physiology-2\/\"},\"wordCount\":663,\"publisher\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/#organization\"},\"image\":{\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-previously-uncharacterized-factor-associated-with-metabolism-and-energy-fame-c14orf105-ccdc198-1700011h14rik-is-related-to-evolutionary-adaptation-energy-balance-and-kidney-physiology-2\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2023\/06\/publication_peterson.jpg\",\"articleSection\":[\"New paper\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-previously-uncharacterized-factor-associated-with-metabolism-and-energy-fame-c14orf105-ccdc198-1700011h14rik-is-related-to-evolutionary-adaptation-energy-balance-and-kidney-physiology-2\/\",\"url\":\"https:\/\/ueb1.sci.muni.cz\/ofiz\/en\/a-previously-uncharacterized-factor-associated-with-metabolism-and-energy-fame-c14orf105-ccdc198-1700011h14rik-is-related-to-evolutionary-adaptation-energy-balance-and-kidney-physiology-2\/\",\"name\":\"A previously uncharacterized Factor Associated with Metabolism and Energy (FAME\/C14orf105\/CCDC198\/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology - 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