{"id":1591,"date":"2019-05-18T14:18:37","date_gmt":"2019-05-18T14:18:37","guid":{"rendered":"http:\/\/www.med.muni.cz\/histology\/ofiz\/?page_id=1591"},"modified":"2020-07-21T14:10:46","modified_gmt":"2020-07-21T14:10:46","slug":"milan-ciz","status":"publish","type":"page","link":"https:\/\/ueb1.sci.muni.cz\/ofiz\/milan-ciz\/","title":{"rendered":"Milan \u010c\u00ed\u017e BF\u00da AV \u010cR"},"content":{"rendered":"<h1>Milan \u010c\u00ed\u017e<\/h1>\n<h5><strong>Webov\u00e9 str\u00e1nky laborato\u0159e:<\/strong><\/h5>\n<h5><a href=\"https:\/\/www.ibp.cz\/cs\/vyzkum\/oddeleni\/biofyzika-imunitnich-systemu\/vyzkum\/group-of-milan-ciz\">https:\/\/www.ibp.cz\/cs\/vyzkum\/oddeleni\/biofyzika-imunitnich-systemu\/vyzkum\/group-of-milan-ciz<\/a><\/h5>\n\n<style>#kt-layout-id_794486-fe > .kt-row-column-wrap{align-content:start;}:where(#kt-layout-id_794486-fe > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}#kt-layout-id_794486-fe > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var( --global-kb-row-default-top, 25px );padding-bottom:var( --global-kb-row-default-bottom, 25px );padding-top:0px;grid-template-columns:minmax(0, calc(40% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)))minmax(0, calc(60% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)));}#kt-layout-id_794486-fe > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){#kt-layout-id_794486-fe > .kt-row-column-wrap{grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){#kt-layout-id_794486-fe > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style>\n<div class=\"wp-block-kadence-rowlayout alignnone\"><div id=\"kt-layout-id_794486-fe\" class=\"kt-row-layout-inner  kt-layout-id_794486-fe\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-gutter-default kt-v-gutter-default kt-row-valign-top kt-row-layout-equal kt-tab-layout-inherit kt-m-colapse-left-to-right kt-mobile-layout-row kt-custom-first-width-40 kt-custom-second-width-60\"><style>.kadence-column_520263-9e > .kt-inside-inner-col{border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;}.kadence-column_520263-9e > .kt-inside-inner-col,.kadence-column_520263-9e > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column_520263-9e > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column_520263-9e > .kt-inside-inner-col{flex-direction:column;}.kadence-column_520263-9e > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column_520263-9e > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column_520263-9e{position:relative;}@media all and (max-width: 1024px){.kadence-column_520263-9e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column_520263-9e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column inner-column-1 kadence-column_520263-9e\"><div class=\"kt-inside-inner-col\">\n<div style=\"height:45px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p style=\"text-align: justify;\"><em>It is known that histone modifications may interfere with epigenetic changes in neutrophils. Histone H3 citrullination leads to chromatin decondensation and promotes DNA cleavage which results in altered gene expression profile. <\/em><\/p>\n<p style=\"text-align: justify;\"><em>We hypothesize that hypoxia enhances the activity of peptidyl arginine deiminase and the production of citrullinated proteins, including histone H3 proteins in neutrophils. Altered gene expression is in-turn, manifested by functional variability in neutrophils. Emerging evidence suggests this as an important pathological mechanism in chronic inflammatory diseases such as arthritis. Since histone protein citrullination is not the only epigenetic mechanism contributing to the functional plasticity in neutrophils, we also evaluate the effects of hypoxia on histone methylation and acetylation status in neutrophils.<\/em><\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column_03ef38-01 > .kt-inside-inner-col{border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;}.kadence-column_03ef38-01 > .kt-inside-inner-col,.kadence-column_03ef38-01 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column_03ef38-01 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column_03ef38-01 > .kt-inside-inner-col{flex-direction:column;}.kadence-column_03ef38-01 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column_03ef38-01 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column_03ef38-01{position:relative;}@media all and (max-width: 1024px){.kadence-column_03ef38-01 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column_03ef38-01 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column inner-column-2 kadence-column_03ef38-01\"><div class=\"kt-inside-inner-col\">\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"323\" src=\"http:\/\/www.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/05\/ciz.jpg\" alt=\"\" class=\"wp-image-1797\" srcset=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/05\/ciz.jpg 600w, https:\/\/ueb1.sci.muni.cz\/ofiz\/wp-content\/uploads\/2019\/05\/ciz-300x162.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/figure><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Milan \u010c\u00ed\u017e Webov\u00e9 str\u00e1nky laborato\u0159e: https:\/\/www.ibp.cz\/cs\/vyzkum\/oddeleni\/biofyzika-imunitnich-systemu\/vyzkum\/group-of-milan-ciz It is known that histone modifications may interfere with epigenetic changes in neutrophils. Histone H3 citrullination leads to chromatin decondensation and promotes DNA cleavage which results in altered gene expression profile. We hypothesize that &hellip; <a href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/milan-ciz\/\">Read More<\/a><\/p>\n","protected":false},"author":3,"featured_media":5975,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-feature.php","meta":{"kt_blocks_editor_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[234],"tags":[],"class_list":["post-1591","page","type-page","status-publish","has-post-thumbnail","hentry","category-vyzkumne-tymy"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Milan \u010c\u00ed\u017e BF\u00da AV \u010cR - Department of Animal Physiology and Immunology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ueb1.sci.muni.cz\/ofiz\/milan-ciz\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Milan \u010c\u00ed\u017e BF\u00da AV \u010cR - Department of Animal Physiology and Immunology\" \/>\n<meta property=\"og:description\" content=\"Milan \u010c\u00ed\u017e Webov\u00e9 str\u00e1nky laborato\u0159e: https:\/\/www.ibp.cz\/cs\/vyzkum\/oddeleni\/biofyzika-imunitnich-systemu\/vyzkum\/group-of-milan-ciz It is known that histone modifications may interfere with epigenetic changes in neutrophils. Histone H3 citrullination leads to chromatin decondensation and promotes DNA cleavage which results in altered gene expression profile. 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